Accès ouvert
2026
article
OpenAlex
A Miner, Henrik Zetterberg, Kaj Blennow, Jenna R. Groh et autres
Importance: In vivo biomarkers for detecting neuropathologies from repetitive head impacts (RHI), including chronic traumatic encephalopathy (CTE), are needed. Objective: To evaluate the utility of plasma phosphorylated tau 217 (p-tau217), assess its performance as a beta-amyloid (Aβ) biomarker in participants with RHI …
us, se, gb, cn, fr
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Accès ouvert
2026
article
OpenAlex
Alpana Singh, Marisa N. Denkinger, Antoine Leuzy, Kari Dieckhoff et autres
Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder characterized by the deposition of amyloid-β (Aβ) in the walls of leptomeningeal and cortical blood vessels that increases risk of intracerebral hemorrhages and progressive cognitive decline. More than 90% of individuals with Alzheimer's disease …
us, se
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Accès ouvert
2025
article
OpenAlex
Marisa N. Denkinger, Sterling C. Johnson, Alpana Singh, James Liu et autres
Abstract Background Plasma p ‐tau217 outperforms other blood biomarkers for detecting Alzheimer’s disease (AD) pathology. To support clinical use and enable population‐level screening, assays must transition from research‐grade formats to fully automated, random‐access platforms that retain high diagnostic performance ‐ ensuring scalability, …
us
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Accès ouvert
2025
article
OpenAlex
Ricquee Gonzalez‐Green, Trisha L. Walsh, Claire M Erickson, Nellie M. High et autres
BACKGROUND: Blood biomarkers are becoming pivotal tools in the diagnosis and management of neurodegenerative diseases, such as Alzheimer's disease (AD). The leading blood biomarker for AD, pTau-217, demonstrates high sensitivity and specificity for identifying individuals at risk for AD dementia, or who …
us, se
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Marisa N. Denkinger, Alpana Singh, James Liu, Kari Dieckhoff et autres
BACKGROUND: Plasma biomarkers are increasingly recognized for identifying Alzheimer's disease (AD) pathology but biomarkers for other common co-occurring pathologies (e.g., TDP-43, alpha-synuclein) are needed. Limited in vivo gold standards for these pathologies limit biomarker discovery to clinical assessments, which lack the specificity …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Alpana Singh, Marisa N. Denkinger, Kari Dieckhoff, James Liu et autres
BACKGROUND: Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder characterized by the deposition of amyloid-β (Aβ) in the walls of leptomeningeal and cortical blood vessels leading to increased risk of microbleeds, intracerebral hemorrhages, and progressive cognitive decline. It is estimated that up …
us
(code pays fourni par la source)