Karol Kraska

OPIOID-FREE AND OPIOID-SPARING ANESTHESIA IN MODERN PERIOPERATIVE CARE — BENEFITS, LIMITATIONS, AND CLINICAL APPLICATIONS

Magda Kijowska, Karolina Klusek, Michal Batory, Jakub Jakubowski et autres

Opioid-free anesthesia (OFA) and opioid-sparing anesthesia (OSA) have emerged from two converging developments in perioperative medicine: first, the need to reduce opioid-related adverse drug events such as postoperative nausea and vomiting (PONV), respiratory depression, ileus, sedation, and possibly persistent postoperative use; and …

ROLE OF ANTIFIBRINOLYTIC THERAPY IN GYNECOLOGIC SURGERY: TRANEXAMIC ACID FOR REDUCING PERIOPERATIVE BLOOD LOSS

Michal Batory, Jakub Jakubowski, Karol Kraska, Nadzieja Krasucka et autres

Perioperative hemorrhage remains an important clinical concern in gynecologic surgery, including hysterectomy, myomectomy, cesarean delivery, and oncologic procedures, as excessive blood loss may contribute to postoperative anemia, transfusion requirements, reoperation, prolonged hospitalization, and increased perioperative morbidity. Tranexamic acid (TXA) is a synthetic …

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PREMENSTRUAL DYSPHORIC DISORDER (PMDD): CURRENT PHARMACOTHERAPY AND EMERGING TREATMENT APPROACHES

Julia Oziębło, Magdalena Kijowska, Karolina Klusek, Michal Batory et autres

Premenstrual dysphoric disorder (PMDD) is a cyclic mood disorder affecting a subset of women in the late luteal phase, marked by severe affective and physical symptoms that resolve with menses. It is distinguished from milder premenstrual syndrome (PMS) by symptom severity and …

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ADVANCES IN THE DIAGNOSIS AND SURGICAL MANAGEMENT OF CHOLESTEATOMA: A CONTEMPORARY REVIEW

Aleksandra Zynkowska, Aleksandra Skrzyniarz, Maria Kiełbus, Julia Oziębło et autres

Cholesteatoma is a chronic, locally destructive disease of the middle ear characterized by the presence of keratinizing stratified squamous epithelium within the tympanic cavity and mastoid process. Despite its histologically benign nature, it may lead to the destruction of bony structures, damage …

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FUTURE PROSPECTS FOR ACNE TREATMENT- ARTIFICIAL INTELLIGENCE, NANOMEDICINE AND PRECISION DERMATOLOGY: A COMPREHENSIVE REVIEW

Aleksandra Skrzyniarz, Maria Kiełbus, Julia Oziębło, Magda Kijowska et autres

Acne vulgaris is one of the most common chronic inflammatory skin diseases with a complex and multifactorial pathogenesis, including keratinization disorders, excessive sebum production, skin microbiome dysbiosis, inflammatory processes, and hormonal and genetic factors. Despite the availability of numerous effective therapies, such …

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THE ROLE OF ELECTROCARDIOGRAPHY IN THE DIAGNOSIS AND MONITORING OF FABRY DISEASE: A COMPREHENSIVE REVIEW

Jakub Jakubowski, Karol Kraska, Nadzieja Krasucka, Aleksandra Zynkowska et autres

Anderson-Fabry disease (FD) is a rare, X-linked lysosomal storage disorder in which the progressive accumulation of globotriaosylceramide (Gb3) leads to widespread multi-organ damage, with cardiac involvement serving as the primary cause of mortality. This comprehensive review aims to summarize the current state …

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ADVANCED BIOMATERIAL PLATFORMS FOR CHRONIC WOUND CARE: SMART DRESSINGS, 3D BIOPRINTING, AND 4D RESPONSIVE TECHNOLOGIES

Nadzieja Krasucka, Jakub Jakubowski, Michal Batory, Karolina Klusek et autres

Chronic non-healing wounds constitute a significant health concern and impose a substantial financial burden on healthcare systems. This creates a pressing need for advanced solutions capable of improving therapeutic efficacy. The aim of this review article is to analyze the current state …

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COMPARATIVE CLINICAL OUTCOMES OF FARICIMAB VERSUS AFLIBERCEPT IN DIABETIC MACULAR EDEMA: A FOCUSED REVIEW

Karol Kraska, Nadzieja Krasucka, Aleksandra Zynkowska, Aleksandra Magdalena Skrzyniarz et autres

This manuscript presents a focused narrative review with systematic literature identification of comparative evidence on faricimab versus aflibercept in adults with diabetic macular edema. The review prioritized randomized phase III evidence and selected only clinically decisive extension, post hoc, and real-world studies …

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IMMUNOPATHOGENESIS OF OCULAR MANIFESTATIONS OF GRANULOMATOSIS WITH POLYANGIITIS AND POTENTIAL TARGETS FOR NOVEL BIOLOGICAL THERAPIES

Maria Kiełbus, Julia Oziębło, Magdalena Kijowska, Karolina Klusek et autres

Granulomatosis with polyangiitis (GPA) is a phenotypically heterogeneous form of ANCA-associated vasculitis characterized by two partially overlapping processes: extravascular granulomatous inflammation and necrotizing vasculitis of small- and medium-sized vessels. This dual pathobiology is particularly relevant in ocular disease, where some manifestations primarily …

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The Use of Metabolic Inducers in Wheat to Increase the Nutritional and Functional Value of Grain

Wojciech Biszczak, Izabela Jośko, Michał Świeca, Karol Kraska et autres

Stimulation of plant metabolism is a research direction for increasing the nutritional and functional value of food. In a two-year field experiment with spring wheat, eight inducers from different groups (bio- and abiotic; exo- and endogenous) were used. The tested inducers had …

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