DuJiang Yang

Endothelial decorin in cardiac aging: mechanistic ambiguities and therapeutic challenges

DuJiang Yang, GuoYou Wang

We read with great interest the seminal study by Luxán et al.1 which identifies endothelial-cell-derived non-glycanated decorin (DCN) as a critical mediator of cardiac inflammation during aging. The authors provide compelling evidence that non-glycanated DCN activates a pro-inflammatory macrophage phenotype via the …

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Post‐Vaccination Syndromes: The Evidence and a Roadmap for Rigorous Research

DuJiang Yang, GuoYou Wang

The recent review by Yong et al. (Rev Med Virol. 2025; 35:e70070) proposes the entity of "Long Vax Syndrome" or Post-COVID-19 Vaccination Syndrome (PCVS). While this synthesis of anecdotal and early observational reports is a timely contribution, it necessitates a critical evaluation …

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Letter to the Editor Regarding: The IMPACT Survey—The Humanistic Impact of Caring for an Individual with Osteogenesis Imperfecta

Yao Liu, DuJiang Yang, GuoYou Wang

We read with considerable interest the work by Westerheim et al. [1] entitled "The IMPACT Survey: The Humanistic Impact of Caring for an Individual with Osteogenesis Imperfecta."The authors have undoubtedly illuminated a critically under-appreciated aspect of the osteogenesis imperfecta (OI) narrative-the profound …

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Moving beyond association: the imperative for mechanistic and longitudinal research on body composition and bone quality in diabetic osteopathy

DuJiang Yang, Guoyou Wang

In their cross-sectional study, Sun et al. (Aging Clin Exp Res. 2025) provide valuable evidence that the coexistence of high body fat and low muscle mass is associated with lower bone mineral density (BMD) in postmenopausal women with type 2 diabetes (T2D). …

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Mechano-metabolic dysregulation in osteoarthritis: Piezo1-mediated mitophagy impairment as a novel therapeutic target

DuJiang Yang, Lin Cheng Yang, Junjie Chen, Shuang Wang et autres

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From comorbidity to catalyst: mechanistic and therapeutic implications of diabetes mellitus in alcohol-related acute-on-chronic liver failure

DuJiang Yang, GuoYou Wang

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Alpha 9 integrin in spinal cord repair: a critical appraisal of mechanisms, circuitry, and translational potential

Lu Qi, Qinwen Gu, DuJiang Yang, Bo Chen et autres

In response to the groundbreaking study by Stepankova et al. (Acta Neuropathol Commun 13:89, 2025) demonstrating that activated α9 integrin enables sensory axon regeneration after spinal cord injury, this letter provides a critical perspective on the mechanistic underpinnings and translational implications of …

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Advancing the Tendinopathy Triad: Comment on “Tendinopathy: The Interplay Between Mechanical Stress, Inflammation, and Vascularity”

DuJiang Yang, Jiexiang Yang, Shuang Wang, GuoYou Wang

Building upon the integrative framework of tendinopathy proposed by Gehwolf et al.-which elegantly connects mechanical stress, inflammation, and vascularity-this commentary extends the discussion by introducing novel mechanistic insights and future research directions that move beyond the established triad. A paradigm shift is …

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Targeting the Hyperglycemic Pre‐Metastatic Niche to Prevent Breast Cancer Bone Metastasis: Mechanisms and Therapeutic Strategies

DuJiang Yang, Jiexiang Yang, GuoYou Wang

The recent pioneering study by Ye et al. (Adv Sci. 2025;12(37):e0504924) provides compelling evidence that systemic hyperglycemia orchestrates a pre-metastatic niche (PMN) in bone, promoting breast cancer metastasis and identifying Receptor for Advanced Glycation End-products (RAGE) inhibition as a viable therapeutic strategy. …

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Unmeasured confounding and ascertainment bias in the study of diabetes diagnosis age and fracture risk

Lu Qi, Qinwen Gu, Bo Chen, DuJiang Yang et autres

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Beyond quantity: The nonlinear association between HDL cholesterol and coronary atherosclerosis

DuJiang Yang, GuoYou Wang

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Standardization to personalization: geroscience-driven future for preoperative optimization in spine surgery

DuJiang Yang, Junyi Yang, GuoYou Wang

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