Accès ouvert
2026
article
OpenAlex
Ryohei Uenishi, Rinna Kawata, Tatsuya Manabe, Yukio Matsuba et autres
Neuroinflammation plays a central role in the progression of tauopathy via the glial activation and T cell accumulation in the brain parenchyma. However, the key molecular mediators that link these processes to tau pathology remain poorly understood.Here, we identify C-X-C motif chemokine …
jp
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Ryohei Uenishi, Rinna Kawata, Tatsuya Manabe, Yukio Matsuba et autres
Abstract Neuroinflammation is a central driver of tauopathy, yet the precise chemokines that orchestrate the inflammatory microenvironment remain elusive. Here, we report C-X-C motif chemokine ligand 10 (CXCL10) is markedly upregulated in the brains of tauopathy model mice, where it co-localizes with …
jp
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Ryohei Uenishi, Rinna Kawata, Tatsuya Manabe, Toru Takeo et autres
Abstract It is known that T cells play an important role in the progression of neurodegenerative disorders, including tauopathies. In this study, we used fingolimod (FTY720), an approved medication for the treatment of multiple sclerosis (MS), to manipulate T cell dynamics in …
jp
(code pays fourni par la source)