2026
conference-abstract
OpenAlex
Sreekar Challa, Jessica D. St. Laurent, Zehra Ordulu, Alexander J. Neil et autres
Abstract The Cancer Genome Atlas (TCGA) identified four molecular subtypes of endometrial carcinoma: POLE, high microsatellite instability (MSI-H), copy number-low and copy number-high. These classifications were eventually adopted into clinical practice in the form of ProMisE, a molecular classifier for endometrial cancers …
us
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Nadja Zhakula, Sejal Jain, Zeinab Amini-Farsani, Jiankang Zhang et autres
Abstract Squamous cell carcinomas (SCCs) across epithelial tissues of the lung, head and neck, and esophagus lack canonical oncogenic mutations and urgently require therapeutic strategies. Aneuploidy—chromosomal gains or losses, is detrimental in normal cells yet occurs in >90% of solid tumors in …
us
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Ryul Kim, Owen Hirschi, Matthew Leventhal, Chunyang Bao et autres
Abstract The goal of The Cancer Genome Atlas (TCGA) has been to continually characterize the genomic and transcriptomic landscapes across diverse malignancies. In this analysis, we assess matched tumor-normal Whole-Genome Sequencing (WGS) data from a previously sequenced set of adult cancer patients …
us, kr
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Anders B. Dohlman, Robin Mjelle, Henry M. Wood, Alaina Shumate et autres
Abstract There is growing evidence that microorganisms represent an important component of the tumor microenvironment. However, conflicting reports regarding the cancer microbiome have left the extent of microbial presence across cancer types unclear, highlighting the need for more robust methods for identifying …
us, no, in, it
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
H Tomono, Chunyang Bao, Antonia Kowalewski, David Lehotzky et autres
Abstract Somatic copy number alterations (SCNAs) are frequent oncogenic events. Previous studies have identified recurrent gene-level SCNAs using DNA microarray and whole exome sequencing data. These studies have also identified focal amplifications of regulatory regions. High-throughput whole genome sequencing enables deeper, comprehensive …
us, gb
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Jakob Heinz, Matthew Meyerson, Heng Li
Long-read sequencing data is useful for detecting large and complex structural variations; however, technical artifacts can lead to false structural variant calls. In our analyses, we became aware of a foldback artifact in long-read data. Therefore, we developed the open-source Breakinator tool …
us
(code pays fourni par la source)
2011
conference-abstract
OpenAlex
Trevor J. Pugh, Michael S. Lawrence, Carrie Sougnez, Gad Getz et autres
Abstract Neuroblastoma (NBL) is a cancer arising from the peripheral nervous system and is the most common solid tumor outside the brain in infants and children. Despite improved treatment over the past 20 years, only 45% of those with high-risk disease survive …
us
(code pays fourni par la source)