Mohammed Ayad Alboreadi

Mitigating doxorubicin-induced toxicity in breast cancer treatment with in situ pH-sensitive carvedilol-loaded transbilosomes: in vitro and in vivo characterization

Tamer Mohamed Mahmoud, Mohammed Ayad Alboreadi, Fatma I. Abo El‐Ela, Amr Gamal Fouad et autres

Doxorubicin (DRC) is widely used as a breast cancer treatment. However, its use is limited due to cardio, hepatic, and renal toxicities. Carvedilol (CVL) has emerged as a potential protective agent against DRC-induced toxicity (DIT). Despite this, CVL has a short half-life, …

iq, bh, Égypte, sa (code pays fourni par la source)

Improving the therapeutic efficacy and bioavailability of carvedilol for control of diabetes-associated heart failure: in vitro and in vivo characterisation

Tamer Mohamed Mahmoud, Mohammed Ayad Alboreadi, Amr Gamal Fouad, Nada H. Mohammed et autres

Carvedilol (CRD) is an oral beta-adrenergic antagonist approved for treating heart failure (HF). However, due to its short half-life and poor solubility, CRD has limited bioavailability and effectiveness. This study aimed to develop a nasal spray of CRD-novasomes (CLN) to enhance CRD's …

bh, Égypte, us, sa (code pays fourni par la source)

Projeto e descoberta de fármacos com ferramentas de bioinformática

Amjad I. Oraibi, Ahmed M. Zheoat, Hayder Naji Sameer, Mohammed Ayad Alboreadi et autres

Context: Bioinformatics is a combination of different fields including computer science, biology, information technology and statistics which is used to analyze and interpret the biological data. It is used to design and discover novel drugs through biological data analysis and potential target …

Efficacy and safety of valsartan–novasomes in the mitigation of atherosclerosis-associated diabetes mellitus: in vitro and in vivo assessment

Tamer Mohamed Mahmoud, Mohammed Ayad Alboreadi, Amr Gamal Fouad, Amany Belal et autres

Valsartan (VAL) offers protection against atherosclerosis-associated diabetes mellitus (AADM) due to its antioxidant properties. However, VAL is hindered by poor bioavailability and effectiveness, which can be attributed to its low water solubility and significant first-pass metabolism. This research aimed to develop a …

bh, iq, Égypte, sa, bd (code pays fourni par la source)