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Paula Linh Kramer, Katharina Buchthal, Dominique Sydow, Katharina Sonja Leo et autres
Protein kinases play a crucial role in key regulatory cell processes and are known to be dysregulated in diseases such as cancer and autoimmune disorders. Hence, protein kinases represent a vital drug target class. To meet the challenge of designing novel kinase …
de (code pays fourni par la source)
Katharina Buchthal, Paula Linh Kramer, Dominik Hubach, Gina Bach et autres
Protein kinases regulate signal transduction through phosphorylation, and their dysregulation drives diseases like cancer, making them key drug targets. Fragment-based drug design offers a powerful route to kinase inhibitors, but often neglects kinase-specific structural insights. While KinFragLib, a library consisting of 7486 …
de (code pays fourni par la source)
Dominique Sydow, Paula Schmiel, Jérémie Mortie, Katharina Buchthal et autres
KinFragLib: Exploring the Kinase Inhibitor Space Using Subpocket-Focused Fragmentation and Recombination. Project description. Protein kinases play a crucial role in many cell signaling processes, making them one of the most important families of drug targets. In this context, fragment-based drug design strategies …
de (code pays fourni par la source)
Paula Linh Kramer, Katharina Buchthal, Dominique Sydow, Katharina Sonja Leo et autres
Paula Linh Kramer, Katharina Buchthal, Dominique Sydow, Katharina Sonja Leo et autres
Protein kinases play a crucial role in key regulatory cell processes and are known to be dysregulated in diseases such as cancer and autoimmune disorders. Hence, protein kinases represent a vital drug target class. To meet the challenge of designing novel kinase …
de (code pays fourni par la source)
Katharina Buchthal, Paula Linh Kramer, Dominik Hubach, Moritz Klöpper et autres
Protein kinases are crucial for signal transduction by catalyzing phosphorylation. Dysregulation is linked to diseases like cancer, autoimmune disorders, and Alzheimer's, making them key drug targets. High interest in this protein family has yielded large amounts of available structure and ligand data. …
de (code pays fourni par la source)
Paula Linh Kramer, Katharina Buchthal, Dominique Sydow, Katharina Sonja Leo et autres
Protein kinases play a crucial role in key regulatory cell processes and are known to be dysregulated in diseases such as cancer and autoimmune disorders. Hence, protein kinases represent a vital drug target class. To meet the challenge of designing novel kinase …
de (code pays fourni par la source)
Paula Linh Kramer, Katharina Buchthal, Dominique Sydow, Katharina Sonja Leo et autres
Protein kinases play a crucial role in key regulatory cell processes and are known to be dysregulated in diseases such as cancer and autoimmune disorders. Hence, protein kinases represent a vital drug target class. To meet the challenge of designing novel kinase …
de (code pays fourni par la source)
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