mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR node
Laura Mantoan Ritter, Nicholas M. P. Annear, Emma L. Baple, Leila Y. Ben-Chaabane et autres
Mechanistic target of rapamycin (mTOR) is a highly conserved serine/threonine kinase that regulates key cellular processes including cell growth, autophagy and metabolism. Hyperactivation of the mTOR pathway causes a group of rare and ultrarare genetic diseases. mTOR pathway diseases have diverse clinical …
gb, be, us (code pays fourni par la source)
11 citations
Orphanet Journal of Rare Diseases