Esther Harpenas

WED-196 Cell-free chromatin liquid biopsy for non-invasive MASH diagnosis and monitoring

Gavriel Fialkoff, Jenia Gutin, Israa Sharkia, Ronen Sadeh et autres

OS-093 Cell-free chromatin for identifying T cell-mediated liver rejection

Abed Khakayla, Achraf Imam, Gavriel Fialkoff, Israa Sharkia et autres

Diagnosis and Prediction of Precursor States in Multiple Myeloma using Cell-free Chromatin

Noa Omer Vilk, Vladimir Veinstein, Nadav Hermoni, Oren Shaul et autres

Abstract Multiple myeloma (MM) is a hematological malignancy that, in many cases, is preceded by monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM), pre-MM conditions with a lifelong risk of progression to symptomatic MM. Accurate diagnosis, prognostication, and adequate …

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Diagnosis and prediction of precursor states in multiple myeloma using cell-free chromatin

Noa Omer Vilk, Vladimir Vainstein, Nadav Hermoni, Oren Shaul et autres

Abstract Multiple myeloma (MM) is a hematological malignancy that, in many cases, is preceded by monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM), pre-MM conditions with a lifelong risk of progression to symptomatic MM. Accurate diagnosis, prognostication, and adequate …

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Urine cf-nucleosomes: A non-invasive window into human physiology and disease

Matan Lotem, Israa Sharkia, Batia Azria, Esther Harpenas et autres

Urine contains fragments of cell-free DNA (cfDNA) that offer molecular insights into processes within the urinary system and the body. It remains unclear whether these fragments exist as chromatin and retain chromatin modifications from their cells of origin. Here, we employ cell-free …

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P-272 Ovarian follicular fluid: liquid biopsy insights via cfChIP-seq in IVF and oocyte preservation

Keren Marks Garber, M Katzinel-Gilad, Elazar Fallik, Miri Godin et autres

Abstract Study question How can cfChIP-seq analysis be used to characterize functional gene expression signatures in follicular fluid and be used to assess ovarian function and oocyte competence? Summary answer CfChIP-seq analysis revealed intact modified nucleosomes with distinct active promoters, including hallmarks …

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OS-090 A cfChIP-seq liquid biopsy for the diagnosis of acute cellular rejection following liver transplantation

Achraf Imam, Jenia Gutin, Ronen Sadeh, Gavriel Fialkoff et autres

886: HISTONE-BASED LIQUID BIOPSY FOR THE DIAGNOSIS OF ACUTE CELLULAR REJECTION FOLLOWING LIVER TRANSPLANTATION

Imam A. Ishraf, Jenia Gutin, Ronen Sadeh, Chase J. Wehrle et autres