Accès ouvert
2026
article
OpenAlex
Yu Shan Tian, Vojislav Gligorovski, Nicolas Mathis, Jing Mei Zhao et autres
Abstract Background Inherited variants in the LDL receptor ( LDLR ) gene are the most common cause of familial hypercholesterolemia (FH), significantly increasing coronary artery disease risk. Early identification of pathogenic LDLR variants enables prompt intervention with lipid-lowering therapies; however, the majority …
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Accès ouvert
2026
preprint
OpenAlex
Quang Vinh Phan, Felicitas Vogd, Phillip Zhou, Minja Simon et autres
The low density lipoprotein receptor (LDLR) removes low-density lipoprotein cholesterol (LDL-C) from circulation, and deleterious LDLR variants are the primary cause of familial hypercholesterolemia, a condition characterized by exceptionally high LDL-C levels and an increased risk of premature cardiovascular disease. Measuring the …
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Accès ouvert
2026
article
OpenAlex
Ann-Sophie Kroell, Kira H Hoffmann, Nikolas Alexander Motzkus, Nina Lemmen et autres
Thermogenetics enables noninvasive spatiotemporal control over protein activity in living cells and tissues, yet its applications have largely been restricted to transcriptional regulation and membrane recruitment. Here, we present a generalizable strategy for engineering thermosensitive allosteric proteins through the insertion of optimized …
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Accès ouvert
2025
preprint
OpenAlex
Ann-Sophie Kroell, Nikolas Alexander Motzkus, Nina Lemmen, Nele Happ et autres
Abstract Thermogenetics enables non-invasive spatiotemporal control over protein activity in living cells and tissues, yet its applications have largely been restricted to transcriptional regulation and membrane recruitment. Here, we present a generalizable strategy for engineering thermosensitive allosteric proteins through the insertion of …
de
(code pays fourni par la source)