Polyphenols as Modulators of Macrophage Polarization: Mechanisms and Therapeutic Potential in Chronic Inflammatory Diseases
Hui Huang, Biying Fan, Changhong Wei, Yixuan Song et autres
Macrophage polarization between pro-inflammatory M1 and anti-inflammatory M2 phenotypes is pivotal in chronic inflammatory diseases, offering a key therapeutic target. Natural polyphenols exhibit promising immunomodulatory capacity. This review illustrates how polyphenols target key signaling pathways (NF-κB, JAK/STAT, PI3K/Akt, and Notch) to subsequently …
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