Ritvik Viniak

Perivascular Macrophages Are Associated With Permissive Sites of Immune Cell Extravasation in Retinal Venules

Colin A. Lemire, Amrita Rajesh, Ritvik Viniak, Jeremy A. Lavine

Purpose: Perivascular macrophages (pvMacs) exist on venules at the blood-retina barrier (BRB) and are important for leukocyte transendothelial migration during retinal inflammation. The venular basement membrane contains low expression regions (LERs), which act as permissive sites for extravasation in non-ocular tissues. We …

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Tissue-resident macrophages maintain choroidal homeostasis by complement dependent and independent mechanisms

Joyce Gong, Sanaz Ghotbaldini, Ritvik Viniak, Amrita Rajesh et autres

Abstract Background Age-related macular degeneration (AMD) is characterized by disruption of the choriocapillaris (CC) and retinal pigment epithelium (RPE) dysfunction, leading to drusen accumulation. The CC and RPE form a tightly interdependent unit that maintains homeostasis where the CC supplies oxygen and …

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Stratified blood donation volumes: Lessons from Japan and India on mitigating vasovagal reactions in older female donors

Palak Preet Kaur, Amitava Chatterjee, Tarun Dhawan, Ritvik Viniak

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The role of myeloid cell heterogeneity during spontaneous choroidal neovascularization in Vldlr knockout mice

Amrita Rajesh, Joyce Gong, Kyle S. Chan, Ritvik Viniak et autres

Myeloid cells are heterogeneous cells that are critical for spontaneous choroidal neovascularization (CNV) in the Vldlr−/− mouse model. However, the specific myeloid cell subtype necessary for CNV remains unknown. To investigate the role of monocytes, we bred Ccr2−/− and Nr4a1−/− mice into …

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