Noam Savion Gaiger

Enrichment of the germline NLRC5 Pro191Leu variant in patients with immune checkpoint inhibitor–induced hepatitis.

Shira Gabizon Peretz, Noam Savion Gaiger, Jacqueline Mann, Harriet M. Kluger

2660 Background: Immune checkpoint inhibitor–induced hepatitis (ICI-hepatitis) is a clinically significant immune-related adverse event (irAE) that may require treatment interruption and immunosuppressive therapy. Predictors of susceptibility to irAEs remain poorly defined. NLRC5 is a key regulator of MHC class I antigen presentation …

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Immune checkpoint inhibitor-induced diabetes can potentially be effectively treated with infliximab: a case report of two patients

Noam Savion Gaiger, Michael E. Hurwitz, Navid Hafez, Harriet M. Kluger et autres

Immune checkpoint inhibitor-induced diabetes is a potentially severe and life-threatening complication of immune checkpoint inhibitor therapy in patients with advanced malignancies. It is typically an irreversible complication due to the complete destruction of pancreatic beta cells that requires ongoing insulin treatment, and …

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1266 Spatial profiling of melanoma brain metastases exhibit elevated neural cell adhesion molecule 1 (NCAM1) protein expression and associations with immune microenvironment and treatment response

David G. Su, Noam Savion Gaiger, David A. Schoenfeld, Mingze Dong et autres

Background Melanoma brain metastases (MBM) affect approximately 60% of patients with metastatic melanoma and exhibit distinct molecular and immune features compared to extracranial metastases (ECM). 1 2 Prior studies have demonstrated a unique immune microenvironment in MBM, including increased CD8+ T-cell infiltration …

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870 Characterization of GDF-15 expression patterns in renal cell carcinoma

Oscar Perales, Noam Savion Gaiger, Stephanie Elzer Schwartz, Yael Derdikman Ofir et autres

Background Growth and Differentiation Factor 15 (GDF-15) is a secreted cytokine in the TGF-beta superfamily that is highly expressed in the placenta during pregnancy and in certain solid tumors. In cancer, it is thought to help mediate immune escape and possibly resistance …

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240: CLINICOPATHOLOGIC ANALYSIS OF MELANOMA METASTASES TO GASTROINTESTINAL SITES FOR A TISSUE MICROARRAY

David G. Su, Irvin Yi, Noam Savion Gaiger, David A. Schoenfeld et autres

Survival of patients with metastatic renal cell carcinoma with or without brain metastases.

Michael E. Hurwitz, Bryden Considine, Nitzan Hasson, Noam Savion Gaiger et autres

476 Background: Brain metastasis (BM) is an adverse prognostic indicator and associated with poor survival for patients with metastatic renal cell carcinoma (mRCC). Although immune checkpoint inhibitor (ICI) therapy has significantly improved survival in patients with metastatic renal cell carcinoma, the prognostic …

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