Marco Cerrano

An Injectable Biopolymer Hydrogel Complex (PN/HA/B3) for Facial Skin Redensification and General Rejuvenation: Clinical Report on Device Safety and Efficacy

Alexandre Porcello, Kelly Lourenço, Cíntia Marques, Wassim Raffoul et autres

This study evaluated the safety and effectiveness of HYDRAGEL A2, an injectable medical device containing hyaluronic acid (HA), polynucleotides (PN), and niacinamide, for improving facial skin quality. These ingredients are increasingly recognized for their synergistic effects in aesthetic medicine, with HA and …

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Deregulation of FOXF1 / FENDRR from t(14;16)(q32;q24) defines a subtype of high-risk lineage ambiguous leukemia

Danika Di Giacomo, Petri Pölönen, Valentina Bardelli, Shunsuke Kimura et autres

ABSTRACT: Despite great progress in understanding the genomic basis of immature T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (T-ALL) and acute leukemias of ambiguous lineage, there are still cases that lack defining genetic markers, complicating risk stratification, and limiting targeted therapeutic options. Recent studies …

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Advances in Medicalized Hair Loss Solutions: A Review of Current Clinical Practices and Regenerative Medicine-Based Protocols with Focus on Off-Label Injectable Treatments

Angelica Ferro, Mohammad Alkhowailed, Alexandre Porcello, Marco Cerrano et autres

Hair loss, or alopecia, constitutes a significant and prevalent concern affecting individuals worldwide. Despite the availability of numerous commercial solutions, many individuals continue to experience substantial psychological distress, leading to adverse impact on personal relationships, social interactions, and occupational performance. The limitations …

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Immunomodulatory effect of dasatinib plus blinatumomab versus ponatinib plus blinatumomab in newly diagnosed Ph+ acute lymphoblastic leukemia

Michela Ansuinelli, Nadia Peragine, Maria Stefania De Propris, Maria C. PUZZOLO et autres

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Real-life management of 476 older adults with Philadelphianegative acute lymphoblastic leukemia: a Campus ALL study

Marco Cerrano, Davide Lazzarotto, Eleonora Boscaro, Erika Borlenghi et autres

Not available.

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Caso di brexu-cel alla prima recidiva in un paziente anziano

Marco Cerrano, lorenzo celona, Giulia Berutto, Roberto Freilone et autres

INTRODUCTION: Relapsed or refractory B-cell acute lymphoblastic leukemia (R/R B-ALL) represents a complex clinical scenario, and the advent of immunotherapy has radically changed the therapeutic options available for these patients. The introduction of CAR-T cell therapy for patients over 25 years old …

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Efficacy and Safety of a Stabilized Composition of 26 mg/mL of High Molecular Weight Hyaluronic Acid for Aesthetic Applications

Basste Hadjab, Samuel Gavard Molliard, Jérémie Bon Bétemps, Marco Cerrano et autres

Background: The growing demand for minimally invasive aesthetic procedures highlights the need for innovative injectable solutions that target skin aging beyond volumization. Hyaluronic acid (HA)-based fillers remain a cornerstone of aesthetic treatments, but traditional formulations often offer limited benefits in improving skin …

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Clinical Safety and Efficacy of Hyaluronic Acid–Niacinamide–Tranexamic Acid Injectable Hydrogel for Multifactorial Facial Skin Quality Enhancement with Dark Skin Lightening

Sarah Hsin, Kelly Lourenço, Alexandre Porcello, Michèle Chemali et autres

Facial aging is a complex process manifesting as skin hyperpigmentation, textural irregularities, and a diminished elasticity, hydration, and evenness of tone. The escalating demand for minimally invasive aesthetic interventions has driven the development of advanced hydrogel-based injectable formulations. This clinical study assessed …

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In Vitro Evaluation and Clinical Effects of a Regenerative Complex with Non-Cross-Linked Hyaluronic Acid and a High-Molecular-Weight Polynucleotide for Periorbital Treatment

Hanadi Sami Abuyousif, Alexandre Porcello, Marco Cerrano, Cíntia Marques et autres

Skin aging is a complex and multifactorial process influenced by both intrinsic and extrinsic factors. The periorbital area of the face is particularly susceptible to premature aging signs due to its delicate skin structure, and is a major concern for many individuals. …

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From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Biomolecules

Cíntia Marques, Alexandre Porcello, Marco Cerrano, Farid Hadjab et autres

Polydeoxyribonucleotides (PDRNs) and polynucleotides (PNs) are similar DNA-derived biopolymers that have garnered significant scientific attention since the 1990s for their potential applications in wound healing and skin rejuvenation. These biopolymers exhibit a broad molecular weight (MW) range, typically spanning from 50 to …

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