Dong Jun Lee

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J H Park, Sunghyuk Moon, Su Jin Kim, Dong Jun Lee et autres

Purpose In September 2015, the first and so far only medication for treatment of Leber's hereditary optic neuropathy (LHON) was approved in the EU.The drug in question is idebenone (©Raxone) and has been given to all newly diagnosed patients of the University …

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A Case of Oncocytic and Inverted Schneiderian Papilloma Originating from the Lacrimal Sac

Dong Jun Lee, Sue Jean Mun, Jung Hyo Ahn

Purpose: To report a case of oncocytic and inverted Schneiderian papilloma originating from the lacrimal sac.Case summary: A 70-year-old male presented with a 5-year history of bilateral epiphora. Best-corrected visual acuity was 0.9 in the right eye and 1.0 in the left …

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Abstract 1563: ADRX-0134 as a novel auristatin-based NaPi2b antibody-drug conjugate with widened therapeutic window

Andrew M. Hau, K.–M. Zhang, Maria Shahmoradgoli, Mario Meng-Chiang Kuo et autres

Abstract Sodium-dependent phosphate transport protein 2B (NaPi2b; SLC34A2) is overexpressed in a variety of cancers, including lung carcinomas, ovarian, and endometrial cancers with restricted normal tissue expression. Based on this differential expression profile, a proof-of-concept for an antibody-drug conjugate (ADC) approach utilizing …

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Abstract 1159: Preclinical characterization of a novel STEAP1 antibody-drug conjugate ADRX-0405 for the treatment of mCRPC

Maria Shahmoradgoli, Andrew M. Hau, Oscar Betancourt, Felipe Acosta et autres

Abstract Prostate cancer remains a leading cause of mortality in men. Despite significant advances in the treatment of metastatic castration-resistant prostate cancer (mCRPC), there remains a need for more durable treatment options with improved quality of life. STEAP1 (Six-Transmembrane Epithelial Antigen of …

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Comparison of intraoperative neurophysiological monitoring between propofol and remimazolam during total intravenous anesthesia in the cervical spine surgery: a prospective, double-blind, randomized controlled trial

Myoung Hwa Kim, Jin‐Young Park, Yoon Ghil Park, Yong Eun Cho et autres

BACKGROUND: Although total intravenous anesthesia (TIVA) with propofol and remifentanil is frequently used to optimize intraoperative neurophysiological monitoring (IONM), the exact effect of remimazolam on IONM remains unknown. Here, we compared the effects of propofol and remimazolam along with remifentanil on IONM …

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Non-Destructive Seed Viability Assessment via Multispectral Imaging and Stacking Ensemble Learning

Y. Chu, Min Su Jo, Ga Eun Kim, Cho Hee Park et autres

The tetrazolium (TZ) test is a reliable but destructive method for identifying viable seeds. In this study, a non-destructive seed viability analysis method for Allium ulleungense was developed using multispectral imaging and stacking ensemble learning. Using the Videometerlab 4, multispectral imaging data …

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Canalicular Cyst After Punctal Plug Insertion

Dong Jun Lee, Jung Hyo Ahn

This study describes the case of a patient with a canalicular cyst after punctal plug insertion. A 73-year-old male patient presented with a cystic mass on the right lower eyelid. He had undergone bilateral punctal occlusion with an absorbable punctal plug for …

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Effect of solution flow rate on the fabrication of outer surface selective layer hollow fiber membranes for dye rejection

Gede Herry Arum Wijaya, Hyun Woong Kwon, Jun Ho Park, Dong Jun Lee et autres

Various industries, such as food, petrochemicals, and pharmaceuticals, have recognized the importance of separation technologies for large molecules such as dye. A thin polyamide layer is commonly used in thin film composite membranes for separation applications, but fabricating a polyamide selective layer …

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Abstract 1909: Advancing a novel tubulin-inhibitor ADC technology: The Adcentrx auristatin platform offers enhanced efficacy and safety profiles compared to vedotin technology

Dong Jun Lee, Sabine Rottmann, Anna Wang, Peter P. Challita et autres

Abstract Auristatins represent an important class of anti-mitotic antibody-drug conjugate (ADC) payloads with potent cytotoxic effects on rapidly dividing cancer cells. Most notably, monomethyl auristatin E (MMAE) stands as the most extensively validated compound, laying the foundation for the vcMMAE (vedotin) linker-payload …

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Abstract 1902: ADRX-0706 Nectin-4 antibody-drug conjugate PK/PD characterization elucidates its widened therapeutic window

Maria Shahmoradgoli, Andrew M. Hau, Dong Jun Lee, Anna Wang et autres

Abstract Nectin-4 is a well validated tumor target, which is highly expressed in several solid cancers, while expression in normal tissues is limited. A first-generation antibody-drug conjugate targeting Nectin-4, called enfortumab vedotin-ejfv (EV), was granted accelerated FDA approval in 2019 for urothelial …

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Influence of Cytokinins on Callus and Shoot Induction of Aster × chusanensis Y. Lim, J.O Hyun, Y.D. Kim & H. Shin

Da Seul Jeong, Hyeon Jeong Im, Jong Cheol Yang, Dong Jun Lee et autres

Evaluation of the Characteristics of High-Flux Reverse Osmosis Membranes with Various Additives

Hyun Woong Kwon, Kwang Seop Im, Gede Herry Arum Wijaya, Seong Min Han et autres