Jasper W. A. van Egeraat

ipeval: Interventional Prediction Evaluation

Jasper W. A. van Egeraat, Nan van Geloven, Ruth H. Keogh

Provides methods to evaluate predictive performance of models that estimate risks under hypothetical intervention scenarios (interventional/causal/counterfactual predictions) with observational data subject to treatment-outcome confounding. Inverse probability of treatment weighting (IPTW) is used to construct a pseudopopulation in which all individuals receive a …

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Smartphone-based assessment of physical activity and cardiovascular health: Findings from the Dutch MyHeart Counts study (Preprint)

Jasper W. A. van Egeraat, Anna V Silven, Niels Chavannes, Tobias Nicolaas Bonten

BACKGROUND Fitness and physical activity patterns are key predictors of cardiovascular disease. Traditionally, these factors have been assessed through participant self-report, which is prone to recall bias and inaccuracy. Smartphone-based monitoring provides a scalable and objective alternative for measuring physical activity, offering …

External validation of the SMART2 model for recurrent cardiovascular risk: performance in socioeconomic, ethnic and psychiatric subgroups

Jasper W. A. van Egeraat, Nan van Geloven, Steven H J Hageman, T N Bonten et autres

BACKGROUND: Secondary prevention is critical for patients with established atherosclerotic cardiovascular diseases (ASCVD). The SMART2 model predicts recurrent ASCVD risk but does not account for psychiatric disorders, socioeconomic deprivation or ethnicity. We aimed to evaluate SMART2 model performance overall and in subgroups …

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Sex differences in care for acute coronary syndrome in patients under 60 years: Primary care presentation, referral patterns, hospitalizations and clinical outcomes

Jasper W. A. van Egeraat, Julie A E van Oortmerssen, Jeanine E. Roeters van Lennep, Maryam Kavousi et autres

OBJECTIVES: Acute coronary syndrome (ACS) incidence and mortality rates have risen among women <60 years. This study sought to examine sex differences in healthcare pathways for first-time ACS in young patients, focusing on pre-ACS care, diagnosis and in-hospital management, and post-discharge outcomes. …

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Recommended methodologies for clinical investigations of high-risk medical devices—Conclusions from the European Union CORE–MD Project

Alan G. Fraser, Sergio Buccheri, Robert A. Byrne, Per Kjærsgaard‐Andersen et autres

Before a high-risk medical device is approved for implantation into patients, there should be evidence not only of its performance and safety with a favourable benefit-risk ratio, but also of its clinical efficacy. Regulatory guidance on study methodologies is lacking, however, so …

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Incidence of primary care chest pain consultations during the COVID-19 pandemic: an interrupted time series analysis with routine care data

Simone van den Bulk, Jasper W. A. van Egeraat, Annelieke H J Petrus, Mattijs Everard Numans et autres

BACKGROUND: The COVID-19 lockdown had profound effects on society and healthcare. Cardiology departments reported declines in chest pain evaluations and acute coronary syndrome (ACS) diagnoses. However, the pattern of chest pain in primary care is not clear yet. This study aims to …

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Inhaled corticosteroids for COVID-19: a real-world data analysis on guideline adherence

Jasper W. A. van Egeraat, Ton Kuijpers, Jako S. Burgers, Hendrikus J. A. van Os et autres

BACKGROUND: The recommendation to consider prescribing inhaled corticosteroids (ICSs) to a subgroup of vulnerable patients with COVID-19 was added to the Dutch medical guideline on 2 November 2021, and was also adopted by other countries during the pandemic. AIM: To evaluate the …

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