Gang Zhou

LncRNA RMRP promotes chondrocyte injury by regulating the FOXC1/RBP4 axis

Jingyi Li, Gang Zhou, Te Chen, Qiao Lin

Introduction: The main pathological feature of osteoarthritis (OA) is chondrocyte injury. LncRNA mitochondrial RNA processing endoribonuclease (RMRP) has been shown to be a chondrogenic differentiation factor. This study aimed to explore the role of RMRP in chondrocyte injury. Material and methods: Cell …

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Algorithm for Target Coverage Problem Based on Deep Learning in Wireless Sensor Networks

Gao S, GU Han, Huaiqing He, Gang Zhou

Aiming at the uncertain mechanism of node activation strategies and redundancy of feasible solution sets in the process of solving target coverage problem in wireless sensor networks, we proposed a deep learning based target coverage algorithm to learn the scheduling strategies of …

Glutamine synthetase accelerates re-endothelialization of vascular grafts by mitigating endothelial cell dysfunction in a rat model

Xinbo Wei, Li Wang, Xing Zheng, Peng Chen et autres

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Abstract 1889 Multi-omic Studies Reveal the Polyamine-Hypusine Axis as a Promising Avenue to Improve T-cell Persistence and Metabolism for Adoptive Cell Therapy

Mercy Kehinde‐Ige, Ogacheko Okoko, Gang Zhou, Huidong Shi

Poor metabolic fitness of T cells is a major barrier to the application of Adoptive Cell Therapy (ACT) to many cancer types, leading to poor proliferation, persistence, and dampened anti-tumor function. Leveraging T-cell metabolism to improve their function is becoming increasingly important …

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Drug Repositioning Based on a Multiplex Network by Integrating Disease, Gene, and Drug Information

Gang Zhou, Chenxu Xuan, Yan Wang, Bai Zhang et autres

Background: The research of new drugs is very expensive and the cycle is relatively long, so it has broad development prospects and good economic benefits to use validated drugs in the treatment of other diseases. Objective: The purpose of drug repositioning is …

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Biological Functions and Cross-Kingdom Host Gene Regulation of Small RNAs in Lactobacillus plantarum-Derived Extracellular Vesicles

Siran Yu, Zhehao Zhao, Piliang Hao, Qiu Yan et autres

Extracellular vesicle-mediated transfer of microRNAs is a novel mode of cell-to-cell genetic transmission. Extracellular vesicles produced by microbes have been shown to contain significant quantities of physiologically active molecules such as proteins, lipids, and RNA, which could be transported to host cells …

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A network-based matrix factorization framework for ceRNA co-modules recognition of cancer genomic data

Yujie Wang, Gang Zhou, Tianhao Guan, Yan Wang et autres

With the development of high-throughput technologies, the accumulation of large amounts of multidimensional genomic data provides an excellent opportunity to study the multilevel biological regulatory relationships in cancer. Based on the hypothesis of competitive endogenous ribonucleic acid (RNA) (ceRNA) network, lncRNAs can …

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[The identification of lung cancer gene-drug module based on multiplex networks algorithm].

Gang Zhou, Jie Gao

Using modular identification methods in gene-drug multiplex networks to infer new gene-drug associations can identify new therapeutic target genes for known drugs. In this paper, based on the gene expression data and drug response data of lung cancer in the genomics of …

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SOJNMF: Identifying Multidimensional Molecular Regulatory Modules by Sparse Orthogonality-Regularized Joint Non-Negative Matrix Factorization Algorithm

Yujie Wang, Tianhao Guan, Gang Zhou, Hongqian Zhao et autres

Cancer is not only a very aggressive but also a very diverse disease. Recent advances in high-throughput omics technologies of cancer have enabled biomedical researchers to have more opportunities for studying its multi-level biological regulatory mechanism. However, there are few methods to …

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Identifying Critical States of Hepatocellular Carcinoma Based on Single- Sample Dynamic Network Biomarkers Combined with Simulated Annealing Algorithm

Jie Gao, Yichen Sun, Yujie Wang, Tianhao Guan et autres

Background: Hepatocellular Carcinoma (HCC) is one of the most common malignant tumors. Due to the insidious onset and poor prognosis, most patients have reached the advanced stage at the time of diagnosis. Objective: Studies have shown that Dynamic Network Biomarkers (DNB) can …

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BET Bromodomain Inhibitors OTX015 Promote Killing of Hepatocellular Carcinoma Cells through Pharmacological Effect and By Inhibiting the Expression of Programmed Death Ligand-1

Wei Zhang, Yuanxi Gao, Jinxing Ji, Gang Zhou et autres

Bromodomain and extra-terminal domain inhibitors target bromodomain-containing proteins and are currently being evaluated as anti-cancer agents. In this study, we found that bromodomain and extraterminal domain inhibitor OTX015 can effectively inhibit the proliferation of hepatocellular carcinoma cells and promote the apoptosis of …

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Failure Mechanism of 10 kV Aerial Insulation Line of Overhead Distribution System in Coastal andTyphoon Environment

Gang Zhou, Deyuan Lin, Jiceng Han, Kanghua Yan et autres