Philip Mavberg

Therapeutic apheresis: An effective strategy for a combined targeting of circulating lipoproteins, inflammatory markers, PFAS, and microplastics in cardiometabolic and neurodegenerative disease?

Stefan R. Bornstein, Waldemar Kanczkowski, Romy Walther, Romy Kronstein‐Wiedemann et autres

Lipoprotein apheresis is a highly effective and well-established extracorporeal therapy designed to remove lipoproteins from human circulation on a large scale, particularly in patients with progressive cardiovascular diseases when conventional treatments fail to achieve adequate lipoprotein reduction. Beyond its lipid-lowering capabilities, therapeutic …

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Neutrophil Extracellular Traps (NETs) as a Potential Target for Anti-Aging: Role of Therapeutic Apheresis

Natalia Jarzebska, Roman N. Rodionov, Karin Voit-Bak, Richard Straube et autres

Neutrophil extracellular traps (NETs) are large structures composed of chromatin, histones and granule-derived proteins released extracellularly by neutrophils. They are generally considered to be a part of the antimicrobial defense strategy, preventing the dissemination of pathogens. However, overproduction of NETs or their …

Single-Center Study of Therapeutic Apheresis in 24 Male Patients from the MENA Region: Reduction of Lipids, Inflammatory Markers, Autoantibodies, and Implications for Fatigue, Genetics, and Aging

Charlotte Steenblock, Romy Walther, Yannick P. Kok, Philip Mavberg et autres

Cardiovascular and metabolic disorders, particularly diabetes and obesity, are highly prevalent in the Middle East and North Africa (MENA) region, exhibiting some of the highest global incidence rates. These conditions significantly increase the severity of infectious diseases, notably COVID-19, leading to a …

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Proteomic Profiling of Age-Related Proteins Following Extracorporeal Apheresis

Romy Walther, Bhawana Singh, Xiaoke Yin, Philip Mavberg et autres

Lipoprotein apheresis (LA) is often the last option to adequately reduce lipoproteins in patients with familial hypercholesterolemia and lipoprotein (a) hyperlipidemia. Characterized by mild side effects, it is now the most effective method of preventing major cardiovascular events (CVEs). This benefit is …

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Neutrophil Extracellular Traps (NETs) as a Potential Target for Anti-Aging: Role of Therapeutic Apheresis

Natalia Jarzebska, Roman N. Rodionov, Karin Voit-Bak, Richard Straube et autres

Neutrophil extracellular traps (NETs) are large structures composed of chromatin, histones and granule-derived proteins released extracellularly by neutrophils. They are generally considered to be a part of the antimicrobial defense strategy, preventing the dissemination of pathogens. However, overproduction of NETs or their …

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A multimodal approach for treating post-acute infectious syndrome

Charlotte Steenblock, Nicole Toepfner, Yannick P. Kok, Philip Mavberg et autres

Long-term complications, such as extensive fatigue and cognitive issues, are known from various infections, including SARS-CoV-2, influenza virus, or Borrelia burgdorferi. The pathology is mostly unknown and differs between patients. Unfortunately, there is currently no common and effective treatment. In this perspective, …

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