Amnah Obidan

Combined Omeprazole and Glycyrrhiza glabra L. Extract Attenuate Ethanol-Induced Gastric Ulceration Through Modulation of TLR4/NF-κB/NLRP3 Signaling and Upregulation of PI3K/AKT/mTOR Gene Expression

Sahar Khateeb, Mody Albalawi, Amnah Obidan, Fahad M. Almutairi et autres

Ethanol (EtOH)-induced gastric ulcer (GU) is a common model used to investigate mechanisms of mucosal injury and repair. Omeprazole (OMP) is a conventional anti-ulcer drug that effectively suppresses gastric acid secretion, but its efficacy may be enhanced by combining it with bioactive …

Égypte, sa (code pays fourni par la source)

Nanocomposites of Opuntia ficus-indica mucilage-mediated selenium nanoparticles and nanochitosan as antidiabetic candidates in streptozocin-induced diabetic rats

Haddad A. El Rabey, Sara E. Elnagar, Ayman Y. Allam, Amnah Obidan et autres

Background: (OFI) fruit has various pharmacological properties as a source of bioactive compounds, which have shown effectiveness in diabetes treatment. Methods: Fruits peel mucilage (FM) was extracted from OFI fruit for the green synthesis of selenium nanoparticles (SeNPs), which were then encapsulated …

sa, Égypte (code pays fourni par la source)

Integrated metabolomic, nanoformulation, and network pharmacology approach reveals multifunctional bioactivities of an Ocimum sanctum nanoemulsion

Mervat Sayed Mohamed, Amnah Obidan, Hajer A. Alfarteesh, Seham O. Alsulami et autres

Background Although Ocimum sanctum (Holy Basil) exhibits broad pharmacological potential, its therapeutic application is constrained by poor solubility, instability, and limited bioavailability. Previous nanoemulsion studies have not integrated comprehensive metabolomic profiling with mechanistic and multi-bioactivity validation. This study developed and characterized an …

Égypte, sa (code pays fourni par la source)

STING inhibition and BD1-selective BET blockade limit ischemia–reperfusion–induced hepatic tissue remodeling by suppressing pro-inflammasome signaling

Adel I. Alalawy, Rabab S. Hamad, Abdulrahman Alasmari, Rehab F. Al-Massabi et autres

sa, Égypte (code pays fourni par la source)

β-Sitosterol Enhances the Anticancer Efficacy of Oxaliplatin in COLO-205 Cells via Apoptosis and Suppression of VEGF-A, NF-κB-p65, and β-Catenin

Sahar Khateeb, Fahad M. Almutairi, Adel I. Alalawy, Amnah Obidan et autres

Colon cancer (CC) is a common malignancy characterized by poor prognostic outcomes and considerable mortality. Oxaliplatin (OXP) is commonly used in the treatment of CC; however, its efficacy may be limited by side effects and the development of resistance. β-sitosterol (β-Sit), a …

sa, Égypte (code pays fourni par la source)

Multifunctional antimicrobial properties of Rosmarinus officinalis L.: in silico bioactivity prediction, molecular docking, and in vitro evaluation

Sanaa J. Almowallad, Suad S. Alanazi, Amnah Obidan, Seham O. Alsulami et autres

sa, Égypte (code pays fourni par la source)

Toxicological evaluation of volatile organic compounds emitted from scented candles: in silico ADMET profiling, oxidative stress, inflammation, and lung injury in rats

Mervat Sayed Mohamed, Awatif M. E. Omran, Amnah Obidan, Seham O. Alsulami et autres

Scented candles are widely used in the Middle East, particularly in the Arab Gulf region, to enhance indoor environments. However, limited ventilation in enclosed air-conditioned spaces can cause emissions to accumulate, posing health risks. Although the chemical composition of candle emissions has …

Égypte, sa (code pays fourni par la source)

Assessment of knowledge, attitudes, and practices of antibiotic resistance among university students in Saudi Arabia

Rana K Albadrani, Aysha H Alyenbawi, Mody Albalawi, Amnah Obidan et autres

OBJECTIVE: Antibiotic resistance is a global health threat, driven by widespread misconceptions and the misuse of antibiotics. This study aims to assess the knowledge, attitudes, and practices of undergraduate students at the University of Tabuk, Saudi Arabia, regarding antibiotic use and resistance, …

sa, Égypte (code pays fourni par la source)

Evaluating the Multifunctional Therapeutic Potential of Phycocyanin: Antidiabetic, Antioxidant, Anticancer and Antimicrobial Effects on Defense Genes, Metabolic, Oxidative, and Histopathological Parameters in Dithizone-Induced Diabetic Rats

Manal Abduallah Alduwish, Nahed Sail Alharthi, Asmaa Ali Alharbi, Mody Albalawi et autres

Dithizone, a heavy metal chelator, induces diabetes in animals to model human diabetes.This study evaluates the effects of a phycocyanin extract (PE) from Spirulina platensis on growth, blood indices, oxidative status, gut microbiota, and tissue histology in dithizone-challenged rats, while also assessing …

sa, Soudan (code pays fourni par la source)

A Reviewed Literature on the Effect of Global Warming on Infectious Diseases' Dissemination

Amr A. Mariee, Amnah Obidan, Hayam Atallah Alwabsi, Akram N. Salah

Climate change presents an urgent and impending threat to virtually all global biological systems. In recent years, there has been a surge in research endeavors aimed at investigating the potential relationship between changes in climate patterns and the spread of infectious diseases. …