Zhengfeng Wang

Supplementary Table 1-4 from Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation

Yiheng Dai, Lilong Liu, Yongbo Luo, Cai Zhang et autres

The basic clinical information of the human specimens analyzed in the manuscript

Data from Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation

Yiheng Dai, Lilong Liu, Yongbo Luo, Cai Zhang et autres

Abstract Malonyl-CoA, a key metabolite, is not only the building block for lipogenesis but also a critical regulator of mitochondrial fatty acid β-oxidation. Given the altered metabolic state of many cancers, malonyl-CoA may play a role in tumor development and drug resistance, …

Figure S4 from Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation

Yiheng Dai, Lilong Liu, Yongbo Luo, Cai Zhang et autres

Supplementary data related to Figure 3

Figure S2 from Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation

Yiheng Dai, Lilong Liu, Yongbo Luo, Cai Zhang et autres

MLYCD was downregulated in PCa

Figure S7 from Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation

Yiheng Dai, Lilong Liu, Yongbo Luo, Cai Zhang et autres

Ran K141 malonylation increased the AR transcriptional activity in PCa cells

Figure S3 from Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation

Yiheng Dai, Lilong Liu, Yongbo Luo, Cai Zhang et autres

Restoration of MLYCD expression depleted intracellular malonyl-CoA to repress lipid accumulation and activat PERK mediated endoplasmic reticulum stress signaling pathways

Figure S1 from Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation

Yiheng Dai, Lilong Liu, Yongbo Luo, Cai Zhang et autres

Supplementary data related to Figure 1-2

Figure S6 from Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation

Yiheng Dai, Lilong Liu, Yongbo Luo, Cai Zhang et autres

Ran K141 malonylation promoted AR nuclear localization, related to Figure 5

Figure S5 from Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation

Yiheng Dai, Lilong Liu, Yongbo Luo, Cai Zhang et autres

MLYCD decreased the levels of Ran K141 malonylation, related to Figure 4

Figure S9 from Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation

Yiheng Dai, Lilong Liu, Yongbo Luo, Cai Zhang et autres

The levels of MLYCD expression and Ran K141 malonylation correlates with the clinical prognosis of PCa patients

Figure S8 from Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation

Yiheng Dai, Lilong Liu, Yongbo Luo, Cai Zhang et autres

Restoration of MLYCD reversed resistance to ENZ in PCa, related to Figure 7

Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation

Yiheng Dai, Lilong Liu, Yongbo Luo, Cai Zhang et autres

Malonyl-CoA, a key metabolite, is not only the building block for lipogenesis but also a critical regulator of mitochondrial fatty acid β-oxidation. Given the altered metabolic state of many cancers, malonyl-CoA may play a role in tumor development and drug resistance, especially …

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