Lilong Liu

1-Hydroxypyrene Promotes Bladder Cancer Progression and Tumor-Associated Immunosuppression via MIF

Yiting Liu, Zongyu Li, Yingchun Kuang, Ke Chen et autres

This study examined how 1-hydroxypyrene (1-OHP) affects bladder cancer (BCa) progression and tumor-associated immunosuppression. Public transcriptomic data and target-prediction databases were used to screen for targets related to 1-OHP and BCa. Machine learning was then used to narrow down the candidate genes. …

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Integrative multi-omics analysis identifies SMIM24 as a favorable prognostic biomarker in clear cell renal cell carcinoma

Zongyu Li, Yiting Liu, Yaxin Hou, Yuhong Ding et autres

Clear cell renal cell carcinoma (ccRCC) exhibits substantial molecular and clinical heterogeneity, contributing to variable disease progression and therapeutic outcomes. We previously identified a de-clear cell differentiation (DCCD) tumor state characterized by loss of canonical clear-cell features and aggressive clinical behavior. This …

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Red blood cell distribution width and 28 days mortality in sepsis-associated delirium: a multicenter study and machine learning analyses

Mengting Chen, Jinlong Chen, Na Li, Lilong Liu et autres

The specific prognostic relevance of red blood cell distribution width (RDW) regarding sepsis-associated delirium (SAD) remains poorly understood. Data were retrieved from the MIMIC-IV and eICU-CRD registries. Kaplan–Meier curves, multivariable Cox regression, restricted cubic splines (RCS), and competing-risk models evaluated the association …

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LGALS1-CD276 Paracrine axis between tumor and endothelial cells promotes tumor angiogenesis and progression in bladder cancer

Zheng Liu, Zheng Liu, Zhipeng Yao, Yaxin Hou et autres

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Multi-Omics Profiling of Long Noncoding RNAs in Clear Cell Renal Cell Carcinoma for Characterization and Clinical Applications

Yuhong Ding, Yang Li, Zhenghao Liu, Yaxin Hou et autres

experiments. Candidate biomarkers lncRNAs were identified to build diagnostic (DMRlnc) and prognostic models (PMRlnc), which were validated in TCGA, CheckMate, and IMmotion151 cohorts. DMRlnc achieved high diagnostic accuracy in both discovery and TCGA-KIRC cohorts (AUC 0.98 and 0.93). PMRlnc stratified patients into …

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Supplementary Table 1-4 from Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation

Yiheng Dai, Lilong Liu, Yongbo Luo, Cai Zhang et autres

The basic clinical information of the human specimens analyzed in the manuscript

Data from Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation

Yiheng Dai, Lilong Liu, Yongbo Luo, Cai Zhang et autres

Abstract Malonyl-CoA, a key metabolite, is not only the building block for lipogenesis but also a critical regulator of mitochondrial fatty acid β-oxidation. Given the altered metabolic state of many cancers, malonyl-CoA may play a role in tumor development and drug resistance, …

Figure S4 from Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation

Yiheng Dai, Lilong Liu, Yongbo Luo, Cai Zhang et autres

Supplementary data related to Figure 3

Figure S2 from Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation

Yiheng Dai, Lilong Liu, Yongbo Luo, Cai Zhang et autres

MLYCD was downregulated in PCa

Figure S7 from Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation

Yiheng Dai, Lilong Liu, Yongbo Luo, Cai Zhang et autres

Ran K141 malonylation increased the AR transcriptional activity in PCa cells

Figure S3 from Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation

Yiheng Dai, Lilong Liu, Yongbo Luo, Cai Zhang et autres

Restoration of MLYCD expression depleted intracellular malonyl-CoA to repress lipid accumulation and activat PERK mediated endoplasmic reticulum stress signaling pathways

Figure S1 from Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation

Yiheng Dai, Lilong Liu, Yongbo Luo, Cai Zhang et autres

Supplementary data related to Figure 1-2