Junxiang Wan

MENTSH: A novel mitochondrial microprotein linked to a SNP associated with type 2 diabetes

Kelvin Yen, Ricardo Ramirez, Brendan Miller, Hiroshi Kumagai et autres

Rationale: Obesity and type 2 diabetes (T2D) are growing threats to human health, and their genetic basis is complex and not fully understood.Furthermore, the mitochondrial genome has been shown to encode for many microproteins that have a variety of biological effects.In this …

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Circulating mitochondrial‐derived microproteins at rest and in response to an acute bout of endurance exercise in individuals with cerebral palsy

Oscar Horwath, Linnéa Corell, Junxiang Wan, Emma Hjalmarsson et autres

Regular exercise using assistive movement devices, such as running frames, has emerged as a promising strategy to improve cardiorespiratory fitness in individuals with cerebral palsy (CP). However, the molecular pathways underlying these adaptations remain poorly understood. Here, we examined a novel class …

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An immune-associated mitochondrial DNA variant with sex differences reveals a putative novel microprotein called MASL

Ana R. Silverstein, Thalida E. Arpawong, Eileen M. Crimmins, Tae Jung Oh et autres

The use of mitochondrial wide association studies (MiWAS) to link mitochondrial DNA variants (mtSNPs) to phenotypes of interest has uncovered important connections between mitochondrial genes and human health. The recent introduction of a re-annotated mitochondrial genome that accounts for small open reading …

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The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome

Sarah J. Shemtov, Eric McGann, Lucy Carrillo, Sangmin Lee et autres

Suppression of insulin-like growth factor-1 (IGF-1) signaling extends mammalian life span and protects against a range of age-related diseases. Unexpectedly, we found that reduced IGF-1 signaling fails to extend the life span of mitochondrial mutator mice. Most of the longevity pathways that …

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Mediterranean diet adherence is associated with mitochondrial microproteins Humanin and SHMOOSE; potential role of the Humanin–Nox2 interaction in cardioprotection

Roberto Vicinanza, Vittoria Cammisotto, Junxiang Wan, Kelvin Yen et autres

Background The health benefits of the Mediterranean Diet (Med-Diet) have been demonstrated in observational studies and randomized controlled trials. Emerging evidence suggests that the biological effects of the Med-Diet may be mediated by the modulation of mitochondrial function. Human mitochondrial DNA (mtDNA) …

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Abstract PS1-04-21: Correlations Between MOTS-c, Body Fat, and Muscle Strength in a Diverse Ethnic Cohort of Breast Cancer Survivors in Hawai'i

Jami Aya Fukui, Lauren Imai, Chloe Shen, Kirsten Baron et autres

Abstract Abstract: Correlations Between MOTS-c, Body Fat, and Muscle Strength in a Diverse Ethnic Cohort of Breast Cancer Survivors in Hawai'i Background: Mitochondria Open Reading Frame within the Twelve S rRNA c (MOTS-c) is known to respond to exercise, influencing metabolic, cardiovascular, …

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Age-diet interactions significantly influence intratumoral gene expression, gut microbiome signature and tumor microenvironment in colorectal cancer

Shivani Soni, Pooja Mittal, Jae Ho Lo, Yanqing Yang et autres

Colorectal Cancer (CRC) is the third most prevalent malignancy, leading to significant morbidity and mortality globally. Epidemiological studies suggest that chronological age and diet are among the major contributing factors correlated with the incidence of CRC. Our study aimed to provide insights …

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Supplemental Figure S2 from Mitochondrial DNA Copy-Number Assessment Is a Potent Predictor for Prostate Cancer in White but Not Black Individuals

Melanie K. Flores, Jessica L. Janes, Mirajul Islam, Junxiang Wan et autres

Supplemental Figure S2 shows the comparison of control Mitochondrial DNA copy number levels in White and Black Individuals

Supplemental Figure S3 from Mitochondrial DNA Copy-Number Assessment Is a Potent Predictor for Prostate Cancer in White but Not Black Individuals

Melanie K. Flores, Jessica L. Janes, Mirajul Islam, Junxiang Wan et autres

Supplemental Figure S3 shows receiver operating characteristic (ROC) curves between univariable models adjusted for PSA (log-transformed) only, Plasma mtDNA only, and WBC mtDNA only, stratified by Black and White individuals.

Supplemental Figure S4 from Mitochondrial DNA Copy-Number Assessment Is a Potent Predictor for Prostate Cancer in White but Not Black Individuals

Melanie K. Flores, Jessica L. Janes, Mirajul Islam, Junxiang Wan et autres

Supplemental Figure S4 shows a comparison of the distribution of Mitochondrial DNA copy number by prostate cancer grade for Black and White Individuals stratified by plasma and WBC.

Supplemental Table S3 from Mitochondrial DNA Copy-Number Assessment Is a Potent Predictor for Prostate Cancer in White but Not Black Individuals

Melanie K. Flores, Jessica L. Janes, Mirajul Islam, Junxiang Wan et autres

Supplemental Table S3 shows univariable and multivariable multinomial logistic regression models for testing the association between mtDNA copy number and prostate cancer grade stratified by race

Supplemental Figure S1 from Mitochondrial DNA Copy-Number Assessment Is a Potent Predictor for Prostate Cancer in White but Not Black Individuals

Melanie K. Flores, Jessica L. Janes, Mirajul Islam, Junxiang Wan et autres

Supplemental Figure S1 shows a comparison of control Mitochondrial DNA copy number levels by BPH status for Black and White individuals