Junwen Yu

Design and in vitro evaluation of a parallel gas-exchange chambers oxygenator with reduced hemolysis and pressure drop

Yuan Liu, Junwen Yu, Yuanfei Zhu, Huaiyuan Guo et autres

Background: Hemolytic complications remain a major limitation of membrane oxygenators in clinical support. Compared with human lungs, most commercial oxygenators generate substantial pressure drops and high shear stress, increasing the risks of hemolysis. Therefore, we aimed to develop a membrane oxygenator that …

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Design of a Motor-Torsion Driven 3D-Printed Left Ventricular Mock Circulation System and Hemocompatibility Assessment

Qingyang Cheng, Junlong Meng, Ming Yang, Yuan Liu et autres

In vitro testing of ventricular assist devices, constructing a mock circulation system that reproduces physiological cardiac function, is critical. However, current ventricular simulators often lack biomimetic fidelity and may introduce hemolysis and coagulation risks during prolonged operation, affecting hemocompatibility assessment. This study …

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A Deep Reinforcement Learning-Optimized Blood Flow Profile for Enhanced Oxygenation Efficiency in Membrane Oxygenators

Junwen Yu, Yuan Liu, Huaiyuan Guo, Qingyang Cheng et autres

The membrane oxygenator serves as the core component of extracorporeal life support systems, and its gas exchange efficiency critically influences clinical outcomes. However, gas transfer is predominantly limited by the diffusion barrier within the blood-side boundary layer, where saturated red blood cells …

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Importance and Application of Exercise Rehabilitation after PCI in Elderly Patients with Coronary Heart Disease

Jiaxin Chen, Zhichang Liu, Junwen Yu

Focusing on exercise rehabilitation for elderly patients with coronary artery disease after coronary angiography, this paper systematically analyzes the multifaceted significance of exercise rehabilitation in restoring physical function, improving mental health, and enhancing quality of life. The paper explores the mechanisms and …

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The Impact of Transient Control Performance of Pulsatile Flow on Hemolysis and Coagulation in Ex Vivo Heart Perfusion

Yuanfei Zhu, Shangting Wang, Yuan Liu, Junwen Yu et autres

BACKGROUND: Ex vivo heart perfusion (EVHP) is a promising approach for preserving donor hearts in a near-physiological state. However, the perfusion pressure and flow require adjustment to meet the requirements of aerobic metabolism, which may cause hemolysis and coagulation, consequently impairing myocardial …

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Effect of Pulsatile Blood Flow Parameters on Membrane Oxygenator Performance: A Cross‐Scale Simulation Study

Yuan Liu, Yuanfei Zhu, Junwen Yu, Shangting Wang et autres

Pulsatile blood flow has the potential to improve microcirculation perfusion and increase the oxygen transfer rate of the oxygenator. However, the specific effects of pulsatile blood flow parameters on the oxygen transfer rate remain unclear. A cross-scale simulation model for the oxygenator …

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The impact of dietary patterns on gut microbiota for the primary and secondary prevention of cardiovascular disease: a systematic review

Junwen Yu, Yue Wu, Zheng Zhu, Hongzhou Lu

Previous studies found that it is promising to achieve the protective effects of dietary patterns on cardiovascular health through the modulation of gut microbiota. However, conflicting findings have been reported on how dietary patterns impact gut microbiota in individuals either established or …

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Aortic Pressure Control Based on Deep Reinforcement Learning for Ex Vivo Heart Perfusion

Shangting Wang, Ming Yang, Yuan Liu, Junwen Yu

In ex vivo heart perfusion (EVHP), the control of aortic pressure (AoP) is critical for maintaining the heart’s physiologic aerobic metabolism. However, the complexity of and variability in cardiac parameters present a challenge in achieving the rapid and accurate regulation of AoP. …

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Exploring the potential of epigenetic clocks in aging research

Yuduo Hao, Kaiyuan Han, Ting Wang, Junwen Yu et autres

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