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Profil bibliographique

Douglas B. Johnson

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

11Publications signalées
2854Citations signalées
2Affiliations récentes

Les institutions déclarées

Les domaines associés

Cancer Immunotherapy and BiomarkersCutaneous Melanoma Detection and ManagementViral Infections and Immunology ResearchCAR-T cell therapy researchSARS-CoV-2 and COVID-19 Research

Les publications récentes

Accès ouvert 2025 article OpenAlex

Lack of Association Between Glucose Homeostasis and Immune Checkpoint Inhibitor Outcomes: A Retrospective Institutional Review

J. B. Justice, Hannah Burnette, Rebecca Irlmeier, Fei Ye et autres

Background/Objectives: Immune checkpoint inhibitors (ICIs) have revolutionized outcomes for patients with melanoma. As such, it is important to understand factors that may influence response as well as toxicity to these therapies. Impaired glucose control is often a sign of pathologic inflammation and …

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0 citations Cancers
Accès ouvert 2025 article OpenAlex

Immune checkpoint inhibitor-associated myocarditis: a novel risk score

John R. Power, Charles Dolladille, Benay Özbay, Adrien Procureur et autres

BACKGROUND AND AIMS: Immune checkpoint inhibitors (ICI) are associated with life-threatening myocarditis but milder presentations are increasingly recognized. The same autoimmune process that causes ICI myocarditis can manifest concurrent generalized myositis, myasthenia-like syndrome, and respiratory muscle failure. Prognostic factors for this 'cardiomyotoxicity' …

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67 citations European Heart Journal
Accès ouvert 2024 article OpenAlex

Treatment sequence with tebentafusp and immune checkpoint inhibitors in patients with metastatic uveal melanoma and metastatic GNA11/GNAQ mutant melanocytic tumors

Florentia Dimitriou, Marlana Orloff, Erica C. Koch Hein, Phil F. Cheng et autres

BACKGROUND: Metastatic uveal melanoma (mUM) is rare. Immune checkpoint inhibitors (ICIs) have shown modest efficacy in mUM. Tebentafusp prolonged overall survival (OS) in a phase 3 study. We aimed to investigate the efficacy and safety of the sequence of tebentafusp and ICIs. …

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13 citations European Journal of Cancer
Accès ouvert 2024 article OpenAlex

Primary Tumor Characteristics as Biomarkers of Immunotherapy Response in Advanced Melanoma: A Retrospective Cohort Study

Rachel Goodman, Seungyeon Jung, Kylie Fletcher, Hannah Burnette et autres

Identifying patients likely to benefit from immune checkpoint inhibitor (ICI) treatment remains a crucial goal for melanoma. The objective of this study is to assess the association between primary tumor features and immunotherapy response and survival in advanced melanoma patients. In this …

us (code pays fourni par la source)

0 citations Cancers
Accès ouvert 2023 article OpenAlex

Immune checkpoint inhibitor-related myocarditis: current understanding and potential diagnostic and therapeutic strategies

Isik Turker, Douglas B. Johnson

INTRODUCTION: Myocarditis associated with immune checkpoint inhibitors presents with an often-severe clinical phenotype with arrhythmias and concurrent myositis. This condition tends to occur early after treatment onset and is associated with a high fatality rate. Diagnosis may be challenging, and treatment algorithms …

us (code pays fourni par la source)

12 citations Expert Opinion on Drug Safety
Accès ouvert 2018 article OpenAlex

Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors

Daniel Wang, Joe‐Elie Salem, Justine V. Cohen, Sunandana Chandra et autres

Importance: Immune checkpoint inhibitors (ICIs) are now a mainstay of cancer treatment. Although rare, fulminant and fatal toxic effects may complicate these otherwise transformative therapies; characterizing these events requires integration of global data. Objective: To determine the spectrum, timing, and clinical features …

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2690 citations JAMA Oncology

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