Zhifeng Wang

Gut microbiota signatures in primary aldosteronism and functional identification of an aldosterone-degrading gut bacterium

Zheng Zhang, Changyi Chen, Minchun Zhang, Jun Zhu et autres

Primary aldosteronism (PA), a major cause of secondary hypertension, is characterized by autonomous aldosterone overproduction. Although the gut microbiota is closely linked to blood pressure regulation, its role in PA remains unclear. We performed metagenomic sequencing on fecal samples from 13 patients …

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Correction: Gut Microbiota and Bile Acid Profiles as Predictors of PCOS Remission: Findings from a Sleeve Gastrectomy Treatment Study

Shaoqian Zhao, Yuyao Zou, Zhifeng Wang, Lingxia Ye et autres

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Gut Microbiota and Bile Acid Profiles as Predictors of PCOS Remission: Findings from a Sleeve Gastrectomy Treatment Study

Shaoqian Zhao, Yuyao Zou, Zhifeng Wang, Lingxia Ye et autres

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Epithelial-mesenchymal transition and sunitinib resistance in renal cell carcinoma: mechanisms and therapeutic strategies

Mingkai Zhang, Yirui Zhang, Fan Shen, Maoli Yan et autres

Renal cell carcinoma (RCC) is a prevalent, highly aggressive malignant tumor that affects the urinary system. RCC has a pronounced propensity for metastasis. Despite the widespread use of sunitinib as first-line therapy for advanced RCC, the occurrence of primary and acquired resistance …

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Research Progress on the Multitarget Mechanisms of Terpenoids in the Treatment of Ischemic Stroke

Jiao Yang, Zhifeng Wang, Ting Shi, Shiyuan Wu et autres

Cerebral ischemic stroke (CIS) is an acute cerebrovascular disease associated with high morbidity and disability rates. It is characterized by neurological damage caused by the interruption of cerebral blood flow, often accompanied by sequelae such as motor dysfunction and cognitive decline, which …

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Glycolysis in polycystic ovary syndrome: pathogenesis and treatment

Liwei Xing, Mingqin Shi, Zhifeng Wang, Danyang Li et autres

Polycystic ovary syndrome (PCOS) is a common gynaecological endocrine disorder that affects women of reproductive age and is often accompanied by clinical symptoms such as acne, obesity, menstrual disorders, and ovulation disorders. Although the molecular mechanisms underlying the pathophysiology of PCOS are …

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Key copper homeostasis genes and inflammatory mechanisms in ischemic stroke: A bioinformatics and experimental study

Ting Shi, Zhifeng Wang, Pelser He, Shuangfeng Xu et autres

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A urine DNA methylation assay for early detection of renal cancer

Tongshuai Shi, Hanzhong Chen, Zhifeng Wang, Hong Wang et autres

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Gut Microbiota and Osteoarthritis: From Pathogenesis to Novel Therapeutic Opportunities

Yujiang Xi, Zhifeng Wang, Yuanyuan Wei, Niqin Xiao et autres

Osteoarthritis (OA) is the most common chronic degenerative joint disease, characterized by cartilage damage, synovial inflammation, subchondral bone sclerosis, marginal bone loss, and osteophyte development. Clinical manifestations include inflammatory joint pain, swelling, osteophytes, and limitation of motion. The pathogenesis of osteoarthritis has …

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Research progress on the role of adipocyte exosomes in cancer progression

Yun Wang, Xiaojiang Li, D. Liu, Zhifeng Wang et autres

Exosomes, minute vesicles ubiquitously released by diverse cell types, serve as critical mediators in intercellular communication. Their pathophysiological relevance, especially in malignancies, has garnered significant attention. A meticulous exploration of the exosomal impact on cancer development has unveiled avenues for innovative and …

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