Niveda M. Kasthuri

Multi-omic spatially resolved analysis of the neuroinflammatory response to intracortical microelectrode arrays

Lindsey N. Druschel, Sydney S. Song, Niveda M. Kasthuri, J. Wang et autres

Intracortical microelectrode arrays (MEAs) are devices implanted into the brain's cortex with the ability to record or stimulate neuronal activity. Unfortunately, MEAs tend to fail over chronic time points, limiting their clinical utility. Chronic failure has largely been attributed to the brain's …

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Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury

Kelly Lintecum, Abhirami Thumsi, K. A. Dunn, Lindsey N. Druschel et autres

Traumatic brain injury (TBI) and subsequent neurodegeneration is partially driven by chronic inflammation both locally and systemically. Yet, current clinical intervention strategies do not mitigate inflammation sequelae necessitating the development of innovative approaches to reduce inflammation and minimize deleterious effects of TBI. …

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Vaccines for immunological defense against traumatic brain injury

Kelly Lintecum, Abhirami Thumsi, K. A. Dunn, Lindsey N. Druschel et autres

Abstract Traumatic brain injury (TBI) and subsequent neurodegeneration is partially driven by chronic inflammation both locally and systemically. Yet, current clinical intervention strategies do not mitigate inflammation sequalae necessitating the development of innovative approaches to reduce inflammation and minimize deleterious effects of …

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Author response for "Cell-Specific Spatial Profiling of Targeted Protein Expression to Characterize the Impact of Intracortical Microelectrode Implantation on Neuronal Health"

Lindsey N. Druschel, Niveda M. Kasthuri, Sydney S. Song, J. Wang et autres

Comprehensive proteomic analysis of the differential expression of 62 proteins following intracortical microelectrode implantation

Sydney Song, Lindsey N. Druschel, Niveda M. Kasthuri, J. Wang et autres

Intracortical microelectrodes (IMEs) are devices designed to be implanted into the cerebral cortex for various neuroscience and neuro-engineering applications. A critical feature of IMEs is their ability to detect neural activity from individual neurons. Currently, IMEs are limited by chronic failure, largely …

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Comprehensive Proteomic Analysis of the Differential Expression of 83 Proteins Following Intracortical Microelectrode Implantation

Sydney Song, Lindsey N. Druschel, Niveda M. Kasthuri, J. Wang et autres

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Depletion of complement factor 3 delays the neuroinflammatory response to intracortical microelectrodes

Sydney S. Song, Lindsey N. Druschel, Jacob H. Conard, J. Wang et autres

The neuroinflammatory response to intracortical microelectrodes (IMEs) used with brain-machine interfacing (BMI) applications is regarded as the primary contributor to poor chronic performance. Recent developments in high-plex gene expression technologies have allowed for an evolution in the investigation of individual proteins or …

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Cell-specific spatial profiling of targeted protein expression to characterize the impact of intracortical microelectrode implantation on neuronal health

Lindsey N. Druschel, Niveda M. Kasthuri, Sydney S. Song, J. Wang et autres

Intracortical microelectrode arrays (MEAs) can record neuronal activity and advance brain-computer interface (BCI) devices. Implantation of the invasive MEA kills local neurons, which has been documented using immunohistochemistry (IHC). Neuronal nuclear protein (NeuN), a protein that lines the nuclei of exclusively neuronal …

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