Takahiro Shimizu

A 29-Gb/mm 2 1-Tb 3-b/Cell 3-D Flash Memory With CMOS Direct Bonded Array (CBA) Technology

Kosuke Yanagidaira, Mario Sako, Yasuhiro Hirashima, Yutaka Shimizu et autres

This article reports a 1-Tb 3-b/cell 3-D flash memory fabricated with CMOS direct bonded array (CBA) technology. Compaction of circuits and wires achieves the highest bit density in the world over 29 Gb/mm2with 332-word line (WL) layers. The bit density is improved …

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Subacute intranasal oxytocin improves neurological recovery after ischemic stroke

Yusuke Morishita, Youichirou Higashi, Daichi Tani, Mio Togo et autres

Oxytocin (OXT) is a neuropeptide known for its anti-inflammatory and neuroprotective properties; however, its role in post-stroke recovery remains poorly defined. In this study, we investigated whether intranasal OXT administration during the subacute phase of stroke improves neurological outcomes and modulates microglial …

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Clinical Courses of Elderly Patients with Heart Failure Managed by Local Partnership Clinical Pathway and Multidisciplinary Care

Yuki Yamamoto, Noboru Watanabe, Satoru Hasegawa, Chieko Tanaka et autres

Heart failure (HF) is the most critical issue in the medical and long-term care for the elderly because HF is an economic and social burden due to its high prevalence and poor prognosis. General practitioners (GPs) have recently managed patients with chronic …

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Centrally administered prostaglandin E2 suppresses the micturition reflex in rats

Takahiro Shimizu, Nobutaka Shimizu, Shun Tsubouchi, Mio Togo et autres

Prostaglandin E 2 (PGE 2 ) facilitates the micturition reflex at the lower urinary tract and spinal cord levels. However, the roles of brain PGE 2 in reflex regulation remain unclear. Therefore, we aimed to investigate the effects of intracerebroventricularly administered PGE …

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PD09-06 BRAIN NITRIC OXIDE INHIBITS THE BRAIN α7 NICOTINIC ACETYLCHOLINE RECEPTOR-MEDIATED SUPPRESSION OF THE RAT MICTURITION REFLEX

Nobutaka Shimizu, Takahiro Shimizu, Keiji Inoue, Motoaki Saito

Neuronal Populations Involved in Motor Function Show Prominent Expression of Sbno1 During Postnatal Brain Development

Sunjidmaa Zolzaya, Dai Ihara, Munkhsoyol Erkhembaatar, Shinsuke Ochiai et autres

Human genome studies have suggested that strawberry notch homologue 1 (SBNO1) is crucial for normal brain development, with mutations potentially contributing to neurodevelopmental disorders. In a previous study, we observed significant developmental abnormalities in the neocortex of Sbno1 as early as one …

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Masticator space abscess caused by perforation of posterior molar triangle due to chronic denture irritation

Takahiro Shimizu, Erika Murase, Yasushi Fujimoto

Odontogenic inflammation tends to spill over into the intermuscular space of mastication and may form abscesses.The patient was an 89-year-old woman who presented with a chief complaint of swelling in the right lower ear and lower jaw.There was a fistula in the …

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TRPC6 is a mechanosensitive channel essential for ultrasound neuromodulation in the mammalian brain

Yumi Matsushita, Kaede Yoshida, Miyuki Yoshiya, Takahiro Shimizu et autres

Ultrasound neuromodulation has become an innovative technology that enables noninvasive intervention in mammalian brain circuits with high spatiotemporal precision. Despite the expanding utility of ultrasound neuromodulation in the neuroscience research field and clinical applications, the molecular and cellular mechanisms by which ultrasound …

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Neuronal Populations Involved in Motor Function Show Prominent Expression of Sbno1 during Postnatal Brain Development

Yu Katsuyama, Sunjidmaa Zolzaya, Dai Ihara, Munkhsoyol Erkhembaatar et autres

Human genome studies have suggested that strawberry notch homologue 1 (SBNO1) is crucial for normal brain development, with mutations potentially contributing to neurodevelopmental disorders. In a previous study, we observed significant developmental abnormalities in the neocortex of Sbno1 as early as one …

TERT upregulation promotes cell proliferation via degradation of p21 and increases carcinogenic potential

Masako Mishima, Atsushi Takai, Haruhiko Takeda, Eriko Iguchi et autres

Telomerase reverse transcriptase (TERT) gene aberration is detectable in >80% of cases with hepatocellular carcinoma (HCC). TERT reactivation is essential for cellular immortalization because it stabilizes telomere length, although the role of TERT in hepatocarcinogenesis remains unelucidated. To elucidate the significance of …

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Supplementary Table S3 from Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations

Yugo Sawai, Yuzo Kodama, Takahiro Shimizu, Yuji Ota et autres

Summary of whole exome sequencing.

Supplementary Figure S1 from Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations

Yugo Sawai, Yuzo Kodama, Takahiro Shimizu, Yuji Ota et autres

Supplementary Figure S1. The images of laser capture microdissection for PanIN lesion of AID Tg mouse.