Alexander Sun Zhang

Optimising rare tumour risk syndromes care: clinical insights and the PREVENTABLE socioeconomic framework

Sara B. Pereira, Liliana Xavier Marques de Sousa, Ricardo Amorim, Luzia Garrido et autres

Rare tumour risk syndromes (RTRS) are heritable conditions caused by known genetic defects, affecting 5 per 10,000 people or less, that confer a high lifetime risk of multiple, often early-onset cancers [ 1 , 2 ]. Despite providing a tangible context for …

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Heritable TP53-related cancer risk syndrome : genotype-phenotype insights for prediction, prevention and personalization

Alexander Sun Zhang

Cancers can be classified as sporadic or hereditary. Approximately 10% are hereditary, caused by pathogenic germline variants, and are collectively referred to as hereditary cancer syndromes (HCS). Among these, the most severe is heritable TP53-related cancer risk syndrome (hTP53rc), also known as …

Heritable TP53-related cancer risk syndrome : genotype-phenotype insights for prediction, prevention and personalization

Alexander Sun Zhang

Cancers can be classified as sporadic or hereditary. Approximately 10% are hereditary, caused by pathogenic germline variants, and are collectively referred to as hereditary cancer syndromes (HCS). Among these, the most severe is heritable TP53-related cancer risk syndrome (hTP53rc), also known as …

The Nordic ChiCaP Network: An interdisciplinary approach to childhood cancer predisposition

Fulya Taylan, Joel Janhonen, Katja Ekholm, Svetlana Bajalica‐Lagercrantz et autres

Testing for Childhood Cancer Predisposition (ChiCaP) syndromes is increasingly common in pediatric oncology as early identification can help adapt treatment and initiate surveillance. As such, ChiCaP testing can have medical, ethical, and psychological consequences for both the patients and their families, and …

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Author response for "Recent Advancements, Limitations, and Future Perspectives of the use of Personalized Medicine in Treatment of Colon Cancer"

Amit Kumar Dey, Abhijit Mitra, Surajit Pathak, Suhanya Veronica Prasad et autres

Recent Advancements, Limitations, and Future Perspectives of the use of Personalized Medicine in Treatment of Colon Cancer

Amit Dey, Abhijit Mitra, Surajit Pathak, Suhanya Veronica Prasad et autres

Due to the heterogeneity of colon cancer, surgery, chemotherapy, and radiation are ineffective in all cases. The genomic profile and biomarkers associated with the process are considered in personalized medicine, along with the patient's personal history. It is based on the response …

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CD163 as a Potential Biomarker in Colorectal Cancer for Tumor Microenvironment and Cancer Prognosis: A Swedish Study from Tissue Microarrays to Big Data Analyses

Shuwen Ma, Yuxin Zhao, Xingyi Liu, Alexander Sun Zhang et autres

(1) Background: CD163, a specific macrophage receptor, affects the progression of malignant tumors. Unfortunately, the regulation and expression of CD163 are poorly understood. In this study, we determined the expressions of CD163 in TMA samples from CRC patients and combined them with …

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Clinical Outcomes in Elderly Rectal Cancer Patients Following Neoadjuvant Radiotherapy: An Analysis of the National Cancer Database in Sweden

Libin Huang, Hai‐Ning Chen, Per I. Loftås, Alexander Sun Zhang et autres

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Association of microRNA-652 Expression with Radiation Response of Colorectal Cancer: A Study from Rectal Cancer Patients in a Swedish Trial of Preoperative Radiotherapy to Public Data Analysis and in Vitro Investigation

Surajit Pathak, Wenjian Meng, Sushmitha Sriram, Jaganmohan Reddy Jangamreddy et autres

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