Frédérik Dufour

Synchrony of biomarker variability indicates a critical transition: Application to mortality prediction in hemodialysis

Alan A. Cohen, Diana L. Leung, Véronique Legault, Dominique Gravel et autres

Critical transition theory suggests that complex systems should experience increased temporal variability just before abrupt state changes. We tested this hypothesis in 763 patients on long-term hemodialysis, using 11 biomarkers collected every two weeks and all-cause mortality as a proxy for critical …

ca, jp (code pays fourni par la source)

PACE4-altCT isoform of proprotein convertase PACE4 as tissue and plasmatic biomarker for prostate cancer

Frédéric Couture, Luojun Wang, Frédérik Dufour, Keena Chabot-Maheux et autres

The proprotein convertase PACE4 has demonstrated value as a viable therapeutic target in prostate cancer (PCa). A novel isoform named PACE4-altCT, which arises in neoplastic lesions, plays an important role in tumor progression and has been validated as a pharmacological target. With …

ca (code pays fourni par la source)

Mortality in Hemodialysis: Synchrony of Biomarker Variability Indicates a Critical Transition

Alan A. Cohen, Diana L. Leung, Véronique Legault, Dominique Gravel et autres

us (code pays fourni par la source)

Mortality in hemodialysis: Synchrony of biomarker variability indicates a critical transition

Alan A. Cohen, Diana L. Leung, Véronique Legault, Dominique Gravel et autres

Abstract Critical transition theory suggests that complex systems should experience increased temporal variability just before abrupt change, such as increases in clinical biomarker variability before mortality. We tested this in the context of hemodialysis using 11 clinical biomarkers measured every two weeks …

ca, us, jp (code pays fourni par la source)

Effects of Sex and Physical Activity Level on Serum Biomarker-Based Physiological Dysregulation: The Impact to Predict Frailty and Mortality in the Quebec NuAge Cohort

Ahmed Ghachem, Frédérik Dufour, Tamàs Fülöp, Pierrette Gaudreau et autres

BACKGROUND: Age-related changes in biological processes such as physiological dysregulation (the progressive loss of homeostatic capacity) vary considerably among older adults and may influence health profiles in late life. These differences could be related, at least in part, to the impact of …

ca (code pays fourni par la source)

Physiological System Dysregulation in Gene Expression Correlates Negatively with Age

Frédérik Dufour, Pierre‐Étienne Jacques, Alan A. Cohen

Abstract We attempted to identify gene expression systems that dysregulate with age in human peripheral blood samples across five public datasets. Dysregulation of gene ontology (GO)-defined systems was measured using the Mahalanobis distance (D M ), a measure of multivariant aberrance. We …

ca (code pays fourni par la source)

Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework

Alan A. Cohen, Brian Keith Kennedy, Ulrich Anglas, Anne M. Bronikowski et autres

ca, sg, us, nl, de, it, ru, fr, gr, ch, cn, au, br, pl (code pays fourni par la source)

Méthode de dosage de PACE4 pour l’évaluation de son potentiel comme biomarqueur du cancer de la prostate

Frédérik Dufour

L’utilité clinique du dosage de l’antigène prostatique spécifique (APS) est maintenant remise en question pour le dépistage du cancer de la prostate (CaP) puisque ce biomarqueur est non spécifique au CaP. Ce test de dépistage demeure tout de même fréquemment utilisé en …

Structure-Based Optimization of a Potent PACE4 Inhibitor Containing a Decarboxylated P1 Arginine Mimetic

Anna Kwiatkowska, Christine Levesque, Frédéric Couture, Kévin Ly et autres

Our recent studies have provided direct evidence for the critical role of PACE4 in the progression of prostrate cancer, identifying this enzyme as a promising target to design novel and effective treatments [1]. Moreover, we developed a potent PACE4 inhibitor with considerable …

ca (code pays fourni par la source)

Optimization of Furin Inhibitors To Protect against the Activation of Influenza Hemagglutinin H5 and Shiga Toxin

Hugo Gagnon, Sophie Beauchemin, Anna Kwiatkowska, Frédéric Couture et autres

Proprotein convertases (PCs) are crucial in the processing and entry of viral or bacterial protein precursors and confer increased infectivity of pathogens bearing a PC activation site, which results in increased symptom severity and lethality. Previously, we developed a nanomolar peptide inhibitor …

ca (code pays fourni par la source)