Ming Fei Zhao

The application of nanotechnology in regulating mitochondrial function in tumor microenvironment for cancer therapy

Dazhong Wang, Meng Yuan, Ji Liu, Ming Fei Zhao et autres

Mitochondria are involved in energy production, signal conduction, and cellular differentiation in the human body, and they determine the direction of tumorigenesis and development. Mitochondria-targeted therapy in cancer cells has been reported since researchers discovered the relationship between mitochondria and cancer. However, …

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Lung uptake of two SPECT markers identifies sensitivity to hyperoxia-induced acute respiratory distress syndrome in rats

Anne V. Clough, Pardis Taheri, Guru Prasad Sharma, Ming Fei Zhao et autres

Introduction Exposure of adult rats to hyperoxia is a well-established model of human Acute Respiratory Distress Syndrome (ARDS). Although rats exposed to 100% O2 display clinical evidence of lung injury after ∼40 h and death by 72 h, rats exposed to 60% …

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B cell–targeted therapies in autoimmune skin disease: current advances and challenges

Zhi Hu, Ming Fei Zhao

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Author Correction: Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors

Wei Xia, Jing Xie, Zhiqing Cai, Xuhua Liu et autres

In the version of the article initially published, in Fig. 4f, the “PTD (FOXO4)” image was misused from the “PTD + TBI (14d)” group in Fig. 1f. In Fig. 7h, the “Blank-14d image was misused from the group “PTD + TBI” in …

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Evaluation of outcome indicators in trials for atopic dermatitis

Jingru Tian, Liqing Shi, Shuntong Kang, Dingyao Zhang et autres

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An in vivo imaging approach for simultaneously assessing tumor response and cytotoxicity-induced tissue response in chemotherapy

Steven Johnson, Chad R. Haney, Alisha N. Spann, Nigar Anjuman Khurram et autres

Abstract In chemotherapeutic treatments, while cancer cells are the primary target, cytotoxic side effects are an important consideration. In the current study, we applied an in vivo imaging tool for characterizing chemotherapeutic response in a preclinical setting. The study focused on simultaneously …

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Antigen-presenting fibroblasts: emerging players in immune modulation and therapeutic targets

Xiaoyun Chen, Fangqi Chen, Sujie Jia, Qianjin Lu et autres

Antigen-presenting fibroblasts are a newly recognized subset that challenges the traditional view of these cells as mere structural components. Under pathological or environmental stimuli, fibroblasts acquire antigen-presenting capabilities through the expression of MHC-II molecules and co-stimulatory factors, enabling them to interact with …

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Experimental and numerical study of a novel inbuilt helical ridge small-caliber graft for artery bypass surgery

Ye Wu, Ming Liu, Qi Li, Ming Fei Zhao

Small-caliber (≤ 6 mm) vascular grafts are commonly used to treat vascular diseases, yet intimal hyperplasia at the distal end-to-side anastomosis remains a significant complication with long-term use. Helical flow has been shown to reduce the risk of cardiovascular complications effectively. Integrating …

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Posttransplant complications: molecular mechanisms and therapeutic interventions

Xiaoyou Liu, Junyi Shen, Hongyan Yan, Jianmin Hu et autres

Posttransplantation complications pose a major challenge to the long-term survival and quality of life of organ transplant recipients. These complications encompass immune-mediated complications, infectious complications, metabolic complications, and malignancies, with each type influenced by various risk factors and pathological mechanisms. The molecular …

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Fault Impact Extraction for Planetary Gearbox Using Motor Current

Dexin Chen, Xiaolong Han, Linjiao Wu, Sen Li et autres

As the widely used transmission components, planetary gearboxes are prone to failure because of working under heavy loads. Hence, fault diagnosis is a key to guaranteeing the reliability of planetary gearboxes. In this field, motor current signal analysis (MCSA) is a new …

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Unlocking the power of immunotherapy: Combinatorial delivery of plasmid IL-15 and gemcitabine to synergistically remodeling the tumor microenvironment

Jingwen Liu, Yanyan Han, Ming Fei Zhao, Leyuan Wang et autres

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Future Precipitation Changes in North America in a Warmer Climate

Wengui Liang, Ming Fei Zhao

Future predictions in regional precipitation changes under global warming have heavily relied on the climate model simulations. Understanding the physical mechanisms of future hydroclimate changes in responses to different forcings will help improve our confidence in the model projections. Here we investigated …

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