Maâmar Souidi

Prophylaxis by Administration of Stable Iodine: Principle, Evolution and Recommendations

Maâmar Souidi, Marc Benderitter, François Caire-Maurisier

Prophylaxis by stable iodine “KI 65 mg, breakable tablet” is a pharmacological countermeasure of radiological protection adapted for the prevention of thyroid cancer after exposure to radioactive iodine. A first modification of the marketing authorization of “KI 65 mg, breakable tablet” for …

fr, us (code pays fourni par la source)

Deep models of integrated multiscale molecular data decipher the endothelial cell response to ionizing radiation

Ian Morilla, Philippe Chan, Fanny Caffin, Ljubica Svilar et autres

The vascular endothelium is a hot spot in the response to radiation therapy for both tumors and normal tissues. To improve patient outcomes, interpretable systemic hypotheses are needed to help radiobiologists and radiation oncologists propose endothelial targets that could protect normal tissues …

fr (code pays fourni par la source)

Metabolomics evaluation of repeated administration of potassium iodide on adult male rats

Clément Rosique, Dalila Lebsir, Sheherazade Benatia, Pierre Guigon et autres

The long-lasting consequence of a new iodine thyroid blocking strategy (ITB) to be used in case of nuclear accident is evaluated in male Wistar rats using a metabolomics approach applied 30 days after ITB completion. The design used 1 mg/kg/day of KI …

fr (code pays fourni par la source)

Assessment of the effects of repeated doses of potassium iodide intake during pregnancy on male and female rat offspring using metabolomics and lipidomics

Clément Rosique, Dalila Lebsir, Philippe Lestaevel, Sheherazade Benatia et autres

Preparedness for nuclear accident responsiveness includes interventions to protect pregnancies against prolonged exposure to radioactive iodine. The aim of this study was to investigate a new design consisting of repeated administration of potassium iodide (KI, 1 mg/kg) for 8 days in late …

fr (code pays fourni par la source)

Applying a multiscale systems biology approach to study the effect of chronic low-dose exposure to uranium in rat kidneys

Stéphane Grison, Dimitri Kereselidze, David Cohen, Céline Gloaguen et autres

Purpose: To examine the effects of low-dose exposure to uranium with a systems biology approach, a multiscale high-throughput multi-omics analysis was applied with a protocol for chronic exposure to the rat kidney.Methods: Male and female rats were contaminated for nine months through …

fr (code pays fourni par la source)

Impact of repeated dose of stable iodine in an in utero rat model using a metabolomic approach

Clément Rosique, Dalila Lebsir, Maâmar Souidi, Jean‐Charles Martin

The Fukushima nuclear power plant blast resulted in the release of 131Iodine for several weeks. This unexpected issue challenged the iodin doctrine [1], in which the counter-measure is to provide a unique iodine tablet to saturate thyroid during the radioactive contamination not …

fr (code pays fourni par la source)

Histological long-term effects in relevant tissues after 131I contamination of two Wistar rat models

Meriem Mezaguer-Lekouaghet, Abdelwahab Badreddine, Saâdia Mameri, Maâmar Souidi et autres

Procedures using iodine-131 (131I) represent about 90% of all therapies in nuclear medicine [1, 2]. It is important to evaluate the long-term biological effects of 131I treatment on non-target organs in order to improve the patient radioprotection. The aim of this work …

Algérie, fr (code pays fourni par la source)

Assessment of the effects of repeated doses of potassium iodide intake during pregnancy on male and female rat offspring using metabolomics and lipidomics

Clément Rosique, Dalila Lebsir, Philippe Lestaevel, Sheherazade Benatia et autres

Preparedness for nuclear accident responsiveness includes interventions to protect pregnancies against prolonged exposure to radioactive iodine. The aim of this study was to investigate a new design consisting of repeated administration of potassium iodide (KI, 1 mg/kg) for 8 days in late …

Formula derived Maillard reaction products in post-weaning intrauterine growth-restricted piglets induce developmental programming of hepatic oxidative stress independently of microRNA-21 and microRNA-155

Stéphane Firmin, Ghada Elmhiri, Delphine Crépin, Maâmar Souidi et autres

We recently reported augmentation of lipid peroxidation products in the liver of intrauterine growth-restricted (IUGR) piglets fed a high load of Maillard reaction products (MRPs) during suckling period. The underlying mechanisms of MRPs effects remain unknown. Here, we studied the long-term impact …

fr, br (code pays fourni par la source)

Uranium's effects on bone integrity

Maâmar Souidi, Ndéye Marième Wade‐Gueye, Line Manens, E. Blanchardon et autres

National audience

fr (code pays fourni par la source)

Effects of uranium on reproductive function in rats exposed from fetal life to adulthood

Audrey Legendre, Christelle Elie, Camille Ramambason, Line Manens et autres

In the environment, uranium may be present in drinking water contaminated naturally, by military activities or by human activity in nuclear power stations, mining sites, and farmland (use of phosphate fertilizers). In epidemiological and experimental studies, few reports have clearly demonstrated the …

fr (code pays fourni par la source)

Metabolomics reveals dose effects of low-dose chronic exposure to uranium in rats: identification of candidate biomarkers in urine samples

Stéphane Grison, Gaëlle Favé, Matthieu Maillot, Line Manens et autres

Data are sparse about the potential health risks of chronic low-dose contamination of humans by uranium (natural or anthropogenic) in drinking water. Previous studies report some molecular imbalances but no clinical signs due to uranium intake. In a proof-of-principle study, we reported …

fr (code pays fourni par la source)