Xuanling Shi

Twenty-year persistence of SARS-CoV-1 immune imprinting shapes antibody responses to SARS-CoV-2 infection

Qi Zhang, Peng Chen, Fenglin Guo, Runhong Zhou et autres

cn, hk, mo (code pays fourni par la source)

Broad and durable protection against SARS-CoV-2 and SARS-CoV by an intranasal chimpanzee adenovirus vaccine expressing tandem RBDs and nucleocapsid

Yaping Liu, Runhong Zhou, Tian Zhao, Ruoke Wang et autres

Current intramuscular COVID-19 vaccines reduce severe disease but offer limited protection against infection, enabling viral persistence, immune escape, and transmission. We developed intranasal rare-serotype chimpanzee adenovirus 68 (AdC68)-based vaccines expressing heterologous tandem receptor-binding domains from SARS-CoV-2, SARS-CoV, and MERS-CoV, fused to the …

cn, hk (code pays fourni par la source)

Identification and characterization of bone marrow plasma cells producing IFN-γ-neutralizing autoantibodies in adult-onset immunodeficiency

Han Wang, Qianqian Yang, Tian Zhao, Jinfang Yu et autres

Adult-onset immunodeficiency (AOID) can be associated with anti-interferon (IFN)-γ autoantibodies (AIGAs). Rituximab (RTX) reduces circulating B cells but often fails to eliminate AIGAs, suggesting the presence of long-lived antibody-secreting cells (ASCs) in immune-privileged sites. Here, we identified 23 distinct IFN-γ-specific monoclonal antibodies …

cn, kr (code pays fourni par la source)

Decoding antibody response to MERS-CoV in wild dromedary camels

Faten Idoudi, Ruoke Wang, Tian Long, Ziqing Yang et autres

Wild dromedary camels in the Arabian Peninsula and Africa have harbored antibodies against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) for decades, predating zoonotic spillover to humans. However, the potency, specificity, and structural characteristics of these antibodies remain poorly understood. Here, we characterize …

Tunisie, cn, hk (code pays fourni par la source)

Decoding antibody response to MERS-CoV in wild dromedary camels

Faten Idou, Ruoke Wang, Long Tian, Ziqing Yang et autres

International audience

Mapping of Phospholipase A2 Receptor Epitopes in Idiopathic Membranous Nephropathy and Clinical Relevance of Epitope Profiles

Peng Chen, Gang Chen, Junxian Hong, Yangzhong Zhou et autres

KEY POINTS: Based on the yeast surface display system, we identified three new antigen epitopes of CTLD4, CTLD5, and CTLD6 of phospholipase A2 receptor in membranous nephropathy. In the cohort, 82% of patients showed epitopes beyond Ricin and 56% higher risk for …

cn (code pays fourni par la source)

DS2 designer pre-fusion F vaccine induces strong and protective antibody response against RSV infection

Yiling Yang, Ruoke Wang, Fenglin Guo, Tian Qi Zhao et autres

DS-Cav1, SC-TM, and DS2 are distinct designer pre-fusion F proteins (pre-F) of respiratory syncytial virus (RSV) developed for vaccines. However, their immunogenicity has not been directly compared. In this study, we generated three recombinant vaccines using the chimpanzee adenovirus vector AdC68 to …

cn (code pays fourni par la source)

Exploring distinct modes of inter-spike cross-linking for enhanced neutralization by SARS-CoV-2 antibodies

Xuanyu Nan, Yujie Li, Rui Zhang, Ruoke Wang et autres

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its Omicron subvariants drastically amplifies transmissibility, infectivity, and immune escape, mainly due to their resistance to most neutralizing antibodies. Thus, exploring the mechanisms underlying antibody evasion is crucial. Although the full-length …

cn (code pays fourni par la source)

Super broad and protective nanobodies against Sarbecoviruses including SARS-CoV-1 and the divergent SARS-CoV-2 subvariant KP.3.1.1

Haodi Dong, Runhong Zhou, Jing Chen, Jing Wei et autres

The ongoing evolution and immune escape of SARS-CoV-2, alongside the potential threat of SARS-CoV-1 and other sarbecoviruses, underscore the urgent need for effective strategies against their infection and transmission. This study highlights the discovery of nanobodies from immunized alpacas, which demonstrate exceptionally …

cn, hk, us (code pays fourni par la source)

Distinct Binding Modes of Inter-Spike Cross-Linking Suggest a Supplementary Mechanism for SARS-CoV-2 Antibody Neutralization

Xuanyu Nan, Yujie Li, Rui Zhang, Ruoke Wang et autres

Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its Omicron subvariants drastically amplifies transmissibility, infectivity, and immune escape, mainly due to their resistance to most neutralizing antibodies. Thus, exploring the mechanisms underlying antibody evasion is crucial. Although the …

cn, gb (code pays fourni par la source)

974P Surufatinib combined with anti-PD-1/PD-L1 antibody in the second-line or monotherapy in third-line treatment of advanced hepatocellular carcinoma: A single-arm, open-label, multi-center phase II study

Fei Zhou, Lin Yang, Jiewen Peng, Hongtao Xu et autres

cn (code pays fourni par la source)

CAR-T Therapy in HIV: Pioneering Advances and Navigating Challenges

Xiao Wang, Jianyang Liu, Feike Hao, Tatchapon Ajavavarakula et autres

Chimeric antigen receptor T (CAR-T) cell therapy, renowned for its successes in cancer treatment, is now entering the field of human immunodeficiency virus (HIV) therapy, presenting both opportunities and challenges. With the emergence of broadly neutralizing antibodies, multi-target CARs, and T cell …

cn (code pays fourni par la source)