Rohit A. Chougule

1747P Real-world performance of an AI-driven U-Net-Based pipeline for automated detection of circulating tumor cells (CTCs) in a screening population

Sewanti Limaye, Rajan Datar, Nooreen Syed, Ashwini Ghaisas et autres

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Next-generation U-Net Encoder: Decoder for accurate, automated CTC detection from images of peripheral blood nucleated cells stained with EPCAM and DAPI.

Tim Crook, Massimo Cristofanilli, Sewanti Atul Limaye, Ashok Kumar Vaid et autres

3061 Background: Direct circulating tumor cell (CTC) detection is a promising biomarker for early cancer detection and monitoring. Traditional fluorescence microscopy and AI-driven methods have limitations such as subjectivity and labor-intensiveness. We developed a deep-learning pipeline using a U-Net–type encoder–decoder architecture for …

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Pre- and post-radical surgery comparative quantification of circulating tumor cells and circulating tumor-associated cells.

Rajan Datar, Vineet Datta, Dadasaheb B. Akolkar, Rohit A. Chougule et autres

e15056 Background: Classical Circulating Tumor Cells (CTCs) are defined as EPCAM+, PanCK+, CD45-, whereas, Circulating Tumor Associated Cells (CTACs) are defined as EPCAM+, PanCK+, CD45+/-. CTACs comprise a heterogenous mix of tumor-associated cells including classical CTCs, cancer stem cells, circulating micro-emboli, tumor …

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Enhancing cancer detection through AI-driven high content analysis of circulating tumor cells.

Sachin Apurwa, Muqeet Shaikh, Sagar Devhad, Shoeb R. Patel et autres

3054 Background: The advancements in automated High Content Analysis (HCA) for Circulating Tumor Cells (CTCs) detection necessitate the integration of high-throughput screening (HTS) and Artificial Intelligence (AI) to improve cancer diagnosis efficiency and accuracy. Traditional approaches to cancer detection have faced limitations …

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1228P A circulating tumor cell (CTC) based assay for diagnostic immunocytochemistry profiling of lung cancer

N. Rohatgi, Razelle Kurzrock, Victoria Datta, Sudha Murthy et autres

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Accurate prostate cancer detection based on enrichment and characterization of prostate cancer specific circulating tumor cells

Sewanti Atul Limaye, Simon Chowdhury, Nitesh Rohatgi, Anantbhushan A. Ranade et autres

BACKGROUND: The low specificity of serum PSA resulting in the inability to effectively differentiate prostate cancer from benign prostate conditions is a persistent clinical challenge. The low sensitivity of serum PSA results in false negatives and can miss high-grade prostate cancers. We …

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Concordancy of immunocytochemistry profiling of circulating tumor cells with immunohistochemistry for analysis of therapeutically relevant biomarkers.

Dadasaheb B. Akolkar, Darshana Patil, Sudha Murthy, Kiran Bendale et autres

3047 Background: Immunohistochemistry (IHC) profiling of tumor tissue is the present standard for evaluation of therapeutically relevant biomarkers such as ER, PR, HER2, AR, ARv7, PD-L1 and MMR for selection of targeted, endocrine and checkpoint inhibitor therapy selection. However, this critical analysis …

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Abstract PS2-40: Analytical and clinical validation of the trucheck™ platform for diagnostic triaging of symptomatic cases suspected of breast cancer

Dadasaheb B. Akolkar, Darshana Patil, Pooja Fulmali, Revati Patil et autres

Abstract Background: trucheckTM is a non-invasive micro-biopsy-like approach for diagnostic triaging of symptomatic individuals suspected of Breast Cancer. trucheckTM is based on the detection of Circulating Ensembles of Tumor Associated Cells (C-ETACs: EpCAM+, Pan-CK+, CD45±) of Breast Cancer origin (GCDFP15+, GATA3+); such …

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Abstract PS3-13: Non-invasive screening for breast cancer risk based on circulating ensembles of tumor associated cells

Dadasaheb B. Akolkar, Darshana Patil, Pooja Fulmali, Revati Patil et autres

Abstract Background: Common modalities for breast cancer screening include self-breast examination (SBE) for detection of palpable lumps as well as Mammography scans for detection of suspicious nodules or masses. While both approaches have low specificity, SBE has lower sensitivity for early stage …

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Analytical and clinical validation of the TruCheck platform for diagnostic triaging of symptomatic cases suspected of colorectal cancer.

Dadasaheb B. Akolkar, Darshana Patil, Pooja Fulmali, Revati Patil et autres

24 Background: Trucheck is a non-invasive approach for diagnostic triaging of symptomatic individuals who are suspected of Colorectal Cancer (CRC) and have been advised an invasive biopsy. Trucheck evaluates blood samples for presence of Circulating Ensembles of Tumor Associated Cells (C-ETACs: EpCAM+, …

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PR01.01 Evaluation of Circulating Tumor Cells for Non-Invasively Discerning Lung Primary from Metastasis

D. A. Patil, Sewanti Atul Limaye, Dadasaheb B. Akolkar, Pooja Fulmali et autres

in (code pays fourni par la source)

OFP01.05 Circulating Ensembles of Tumor Associated Cells Facilitate Efficient Triaging of Asymptomatic Individuals for Low Dose Computed Tomography

Dadasaheb B. Akolkar, D. A. Patil, Sewanti Atul Limaye, Pooja Fulmali et autres

in (code pays fourni par la source)