Yoshihiro Amano

Screening opportunity gap in COPD evaluation after low-dose CT findings: implications for risk-based spirometry in primary care

T Hotta, Mika Nakao, Shintaro Shimizu, Kashu Kitani et autres

Abstract Background Low-dose chest computed tomography (CT) frequently detects findings suggestive of chronic obstructive pulmonary disease (COPD). However, the pathway from CT detection to physiological confirmation remains poorly characterized in real-world clinical practice. This study evaluated follow-up pathways after CT findings suggestive …

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Time course of postmortem procedures in a palliative care unit

Tamio Okimoto, Shintaro Shimizu, Ken Yoshihara, Mika Horie et autres

Background: In Japanese hospitals, the processes following recognition of absence of vital signs, including the pronouncement of death, postmortem care, handing over the body to the family or funeral service, and the final postmortem process, often require considerable time. With increasing attention …

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Diversity of Factors Associated with Physical Inactivity in Patients with Asthma Based on Activity Intensity

Keita Murakawa, Tsunahiko Hirano, Keiko Doi, Ayumi Fukatsu-Chikumoto et autres

Background: The factors contributing to physical inactivity in patients with asthma remain unclear. We aimed to explore the pulmonary and extra-pulmonary factors associated with physical activity (PA) in these patients, with stratification by activity intensity. Methods: Patient demographics, Charlson Comorbidity Index, lung …

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Unsupervised comprehensive CT imaging clusters reveal distinct morphological phenotypes in asthma: insights from two prospective cohorts

Yusuke Hayashi, Naoya Tanabe, Atsuyasu Sato, Tsunahiko Hirano et autres

BACKGROUND: Asthma is a heterogeneous disease with diverse underlying structural abnormalities. Comprehensive evaluation of computed tomography (CT)-derived features may uncover novel morphological phenotypes with clinical relevance. This study aimed to identify and validate the morphological phenotypes of asthma using comprehensive inspiratory and …

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A Predicted FEV1/FVC Model Based on a Simple Respiratory Questionnaire for Early Diagnosis of COPD in Shimane Cohort, Japan

Mika Nakao, Tamio Okimoto, Akari Tanino, Yoshihiro Amano et autres

Purpose: Early detection of chronic obstructive pulmonary disease (COPD) remains challenging in primary care settings where spirometry is not always available. We aimed to develop a simple questionnaire-based approach to estimate the forced expiratory volume in one second (FEV 1 )/forced vital …

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イリノテカンメトロノーム化学療法およびイリノテカン＋エベロリムスによる小細胞肺癌の血管新生抑制

Yoshihiro Amano

Background/Aim: Few drugs are effective against small-cell lung cancer (SCLC) after second-line treatment, and suppressing rapid angiogenesis in tumor tissues has been considered an option.Metronomic chemotherapy can suppress angiogenesis while reducing toxicity, and irinotecan has antitumor effects against SCLC.Everolimus is an mTOR …

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Localized Reaccumulation of Pericardial Effusion After Pericardial Fenestration Undetected on Frontal Chest Radiography

Chihiro Kobayashi, Yoshihiro Amano, Kashu Kitani, Takeshi Isobe et autres

A 70-year-old man with advanced lung adenocarcinoma visited our hospital complaining of dyspnea. He was diagnosed with cardiac tamponade and underwent pericardial drainage. Pericardial effusion reaccumulated in 73 days, and right pericardial fenestration was performed. Although his respiratory condition worsened three weeks …

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Localized Reaccumulation of Pericardial Effusion After Pericardial Fenestration Undetected on Frontal Chest Radiography

Kobayashi Chihiro, Shimizu Shintaro, Yoshihiro Amano, Kitani Kashu et autres

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Brain-Derived Neurotrophic Factor Levels Are Associated With Depressive Symptoms in Patients With Asthma

Kazuma Kawamoto, Hiroshi Iwamoto, Tsunahiko Hirano, Yoshihiro Amano et autres

BACKGROUND: Patients with major depressive disorder exhibit reduced central and circulatory levels of brain-derived neurotrophic factor (BDNF), with serum BDNF being proposed as a potential biomarker for major depression. Contrastingly, animal studies have suggested that elevated BDNF levels may be associated with …

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Uneven distribution of air trapping and its impact on physical activity in patients with asthma

Ayumi Fukatsu-Chikumoto, Tsunahiko Hirano, Hiroshi Iwamoto, Taiga Kobayashi et autres

BACKGROUND: The underlying pathophysiology of varying physical activity levels in patients with asthma remains unclear. In this study, we investigated the association between physical activity and air trapping, identified via chest computed tomography, in patients with asthma. METHODS: ) and low-attenuation areas. …

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Phase II study of carboplatin + weekly paclitaxel for advanced lung squamous cell carcinoma with idiopathic interstitial pneumonia (Hanshin Cancer Group IP001)

Hidekazu Suzuki, Akito Hata, Takaaki Tokito, Kana Watanabe et autres

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Physical Activity and Sedentary Time Correlate with Body Composition in Patients with Asthma; a Multicenter Observational Study

Mayuka Yamane, Hiroshi Iwamoto, Kazuma Kawamoto, Toshihito Otani et autres

Background: Increasing physical activity is recommended as a non-pharmacological approach for improving the symptoms, quality of life, and overall health in patients with asthma. However, the systemic effect of physical activity, especially sedentary behavior, in patients with asthma remains unclear. Objective: The …

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