Patrícia Tieme Fujimura

Differential gene expression by RNA-seq during Alzheimer’s disease-like progression in the Drosophila melanogaster model

Jéssica Regina da Costa Silva, Patrícia Tieme Fujimura, Letícia Leandro Batista, Serena Mares Malta et autres

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Cell-free DNA promotes malignant transformation in non-tumor cells

Aline Gomes de Souza, Víctor Alexandre Félix Bastos, Patrícia Tieme Fujimura, Izabella C. C. Ferreira et autres

Cell-free DNA is present in different biological fluids and when released by tumor cells may contribute to pro-tumor events such as malignant transformation of cells adjacent to the tumor and metastasis. Thus, this study analyzed the effect of tumor cell-free DNA, isolated …

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Rat postnatal prostate development is impaired by in vitro high-glucose environment

Isabella Silva Cassimiro, Amanda Rodrigues Cruz, Beatriz Pelegrini Bosque, Laura Calazans de Melo Gomes et autres

The prostate development has an important postnatal period where cell proliferation begins at the first days after birth and is related to gland growth and ramification. Any metabolic and/or hormonal changes occurring during the postnatal period can interfere with prostate branching. Hyperglycemia …

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Screening and characterization of activin A inhibitory peptides by phage display technology

Víctor Alexandre Félix Bastos, Aline Gomes de Souza, Patrícia Tieme Fujimura, Robinson Sabino‐Silva et autres

Background: Activin A has been reported to play a proinflammatory role in the development and progression of idiopathic pulmonary fibrosis (IPF). Follistatin, an activin A inhibitor, is activated by a feedback loop causing increased activin A production, resulting in fibrosis. Aims: To …

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New findings from the first transcriptome of the Bothrops moojeni snake venom gland

Fernanda Gobbi Amorim, Romualdo Morandi Filho, Patrícia Tieme Fujimura, Carlos Ueira‐Vieira et autres

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Characterization of antennal sensilla, larvae morphology and olfactory genes of Melipona scutellaris stingless bee

Washington João de Carvalho, Patrícia Tieme Fujimura, Ana Maria Bonetti, Luíz Ricardo Goulart et autres

There is growing evidence in the literature suggesting that caste differentiation in the stingless bee, Melipona scutellaris, and other bees in the genus Melipona, is triggered by environmental signals, particularly a primer pheromone. With the proper amount of food and a chemical …

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Epigenetic modifications and their relation to caste and sex determination and adult division of labor in the stingless bee Melipona scutellaris

Carlos Antônio Mendes Cardoso-Júnior, Patrícia Tieme Fujimura, Célio Dias Santos Júnior, Naiara Araújo Borges et autres

Stingless bees of the genus Melipona, have long been considered an enigmatic case among social insects for their mode of caste determination, where in addition to larval food type and quantity, the genotype also has a saying, as proposed over 50 years …

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A novel breast cancer screening platform: An epitope-based biomarker coupled to electrochemical sensor.

Yara Cristina de Paiva Maia, Thaise Gonçalves Araújo, Diego Leoni Franco, Fausto Emílio Capparelli et autres

9 Background: The subtractive proteomic selection technology called Phage Display (PD) has been extensively used by our group in the discovery of high affinity ligands to target tissues and molecules. We have selected specific ligands against IgG purified from BC tissues, which …

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Seleção e caracterização de peptídeos miméticos a proteínas tumorais no estadiamento clínico-patológico do câncer de próstata

Patrícia Tieme Fujimura

Prostate cancer is the second cause of deaths by tumor in men, surpassed only to lung cancer. Currently, PSA (prostate-specific antigen) is clinical test of choice for PCa detection and treatment. However, the limitations of the PSA test such as large number …