Karen Carrier

CT-Assisted Visceral Fat Area Measurement Outperforms BMI as a Predictor of Wound Complications in a Predominantly Hispanic and American Indian Post-Renal Transplant Population

Karen Carrier, Madison Aycock, Meryl Davis, Priyamvada Singh

Purpose: Wound complications, such as surgical site infections (SSIs) and wound dehiscence, are significant contributors to morbidity following kidney transplantation (KT), particularly in patients with elevated body mass index (BMI). However, BMI has limitations as a predictor of wound complications. This study …

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Efficacy Findings in a Phase 3, Randomized Trial of Eltrombopag Vs. Standard First-Line Treatment for Newly Diagnosed Immune Thrombocytopenia in Children

Kristin Ammon Shimano, Amanda Bell Grimes, Melissa J. Rose, Shipra M. Kaicker et autres

Background: First-line treatments for patients (pts) with newly diagnosed immune thrombocytopenia (ITP) include corticosteroids, intravenous immunoglobulin (IVIg), and anti-D globulin. Eltrombopag (epag), a thrombopoietin receptor agonist, was FDA approved for children with chronic ITP in 2015. The efficacy of epag in the …

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Assay of Oxolinic Acid Residues in Salmon Muscle by Liquid Chromatography with Fluorescence Detection: Interlaboratory Study

Germain Carignan, Lyse Larocque, Sved Stephen, Karen Carrier et autres

A previously developed method that uses a simplified sample preparation and fluorometric detection of liquid chromatographic eluates for the determination of oxolinic acid in salmon muscle has been collaboratively studied. Five laboratories participated in the study to analyze, in quintuplicate, blank salmon …

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Evidence that amikacin ototoxicity is related to total perilymph area under the concentration-time curve regardless of concentration

Arthur R. Beaubien, Eric D. Ormsby, Aaron P. Bayne, Karen Carrier et autres

Previous studies have failed to fully establish whether ototoxicity is related in any way to the levels of an aminoglycoside antibiotic in the perilymph. To study this we exposed guinea pigs to continuously infused amikacin at four different dosing rates under conditions …

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Delay in Hearing Loss Following Drug Administration

Arthur R. Beaubien, Suzanne Desjardins, Eric D. Ormsby, Aaron P. Bayne et autres

The time course of threshold increase in the VIII nerve compound action potential was studied in guinea pigs following amikacin administration at four different constant infusion rates. Despite the wide range of dosing durations required to achieve drug ototoxicity (2-24 days), the …

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Incidence of amikacin ototoxicity: A sigmoid function of total drug exposure independent of plasma levels

Arthur R. Beaubien, Suzanne Desjardins, Eric D. Ormsby, Aaron P. Bayne et autres

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