Carly Grubbs

Developing and Education Class for Stem Cell Transplant Patients and Caregivers

April Klingensmith, Judy Kauffman, Margit Henry, Carly Grubbs et autres

Topic Significance & Study Purpose/Background/Rationale Background A stem cell transplant presents significant physical, emotional, and logistical challenges for patients and their caregivers. Comprehensive education is critical to ensure they are well-prepared to navigate the transplant process, manage post-transplant care, and mitigate potential …

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Reduction in Discharge Delays for Patients Admitted for Allogeneic and Autologous Stem Cell Transplantation: A Quality Improvement Initiative

Jenna Schlefman, Shipra Maheshwari, Caroline Jones, Isabel Burgess et autres

Introduction The discharge process following stem cell transplant (SCT) is complex, often confounded by events occurring prior to and on day of discharge. Among patients undergoing allogeneic and autologous SCT at the University of Virginia from 01/2022 to 12/2022, only 5% were …

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Prospective Quality Improvement Project Addressing Central Line-Associated Bloodstream Infection Risk with the Reduction of Central Line Days in Autologous Stem Cell Transplant Patients

Henry Brooke, M. Pøhl, Judy Kauffman, John L. Wagner et autres

Topic Significance & Study Purpose/Background/Rationale In Fall 2022, central line-associated bloodstream infection (CLABSI) rates among autologous stem cell transplant (aSCT) patients at our academic medical center exceeded targets. Prior to May 2023, most autologous stem cells were collected via tunneled trifusion catheters, …

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Improving discharge times for patients admitted for allogeneic stem cell transplantation.

Shipra Maheshwari, Jenna Schlefman, Caroline Jones, Isabel Burgess et autres

290 Background: Among patients admitted for allogeneic stem cell transplant (SCT) at University of Virginia (UVA) Health from 01/2022 through 12/2022, 0% were discharged by noon, even when discharge was anticipated. The discharge of SCT recipients is dynamic, impacted by events occurring …

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226 Efficacy of cancer preventing drugs administered by intermittent dosing regimens

V.E. Steele, Carly Grubbs, Chinthalapally V. Rao, Ron Lubet

A gene expression signature predicts chemopreventive response of an EGFR inhibitor in a rat mammary cancer model.

Yan Lü, P Liu, Y Wang, Carly Grubbs et autres

Abstract Abstract #1111 Rats treated with the carcinogen methylnitrosourea (MNU) develop multiple, hormonally dependent mammary tumors. The efficacy of the epidermal growth factor receptor (EGFR) inhibitor Gefitinib (Iressa) to prevent MNU-induced mammary cancers in female Sprague-Dawley rats was determined. Rats were given …

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Retinyl ethers as cancer chemopreventive agents. Suppression of mammary cancer.

Y. Fulmer Shealy, JB Frye, James M. Riordan, Donald L. Hill et autres

It had been demonstrated previously that retinyl methyl ether (RME) can suppress carcinogen-induced mammary cancers in vivo. It had also been shown that RME is demethylated enzymatically to retinol and produces the toxic effects of retinol; however, a rationale was developed for …

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Soybeans inhibit mammary tumors in models of breast cancer.

Stephen H. Barnes, Carly Grubbs, Kenneth D.R. Setchell, Jennifer H. Carlson

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