Phillipa C. White

Tranexamic acid versus placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial

Lise J Estcourt, Zoe McQuilten, Peter Bardy, Merrole Cole‐Sinclair et autres

Correction to: Characterization, Quantification, and Visualization of Neutrophil Extracellular Traps

Josefine Hirschfeld, Ilaria J. Chicca, Carolyn G. J. Moonen, Phillipa C. White et autres

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Characterization, Quantification, and Visualization of Neutrophil Extracellular Traps

Josefine Hirschfeld, Ilaria J. Chicca, Carolyn G. J. Moonen, Phillipa C. White et autres

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Modulation of Neutrophil Extracellular Trap and Reactive Oxygen Species Release by Periodontal Bacteria

Josefine Hirschfeld, Phillipa C. White, Michael R. Milward, Paul R. Cooper et autres

ABSTRACT Oral bacteria are the main trigger for the development of periodontitis, and some species are known to modulate neutrophil function. This study aimed to explore the release of neutrophil extracellular traps (NETs), associated antimicrobial proteins, and reactive oxygen species (ROS) in …

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Characterization, Quantification, and Visualization of Neutrophil Extracellular Traps

Phillipa C. White, Ilaria J. Chicca, Martin R. Ling, Helen J. Wright et autres

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Peripheral blood neutrophil extracellular trap production and degradation in chronic periodontitis

Phillipa C. White, Dimitra Sakellari, Helen Roberts, Idyli Risafi et autres

AIMS: To investigate ex vivo peripheral neutrophil extracellular trap (NET) production and their subsequent degradation by plasma in chronic periodontitis patients, and periodontally and systemically healthy-matched controls. MATERIALS AND METHODS: Chronic periodontitis patient and control (n = 40 pairs) peripheral blood neutrophils …

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The role of neutrophil extracellular traps in the pathogenesis of periodontal diseases

Phillipa C. White

This thesis investigated neutrophil extracellular traps (NETs) in the pathogenesis of periodontal diseases, including chronic periodontitis, experimental gingivitis and Papillon Lefèvre syndrome (PLS). \\(In\\) \\(vitro\\) assays investigated the interactions between periodontal bacteria and peripheral neutrophils isolated by discontinuous Percoll gradients, and demonstrated …

Characterization of neutrophil function in Papillon-Lefèvre syndrome

Scott J. Roberts, Phillipa C. White, Irundika H.K. Dias, Sarah McKaig et autres

Papillon-Lefévre syndrome is a rare, inherited, autosomal-recessive disease, characterized by palmoplantar keratosis and severe prepubertal periodontitis, leading to premature loss of all teeth. Papillon-Lefévre syndrome is caused by a mutation in the cathepsin C gene, resulting in complete loss of activity and …

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Differential activation of neutrophil extracellular traps by specific periodontal bacteria

Phillipa C. White, Paul R. Cooper, Mike Milward, Iain Chapple

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