Nancy D. Kock

Postmortem Findings from the Wake Forest University Radiation Late Effects Cohort of Rhesus Monkeys (Macaca mulatta)

George William Schaaf, John D. Olson, Brooke T. Kahn, Nancy D. Kock et autres

The Wake Forest Radiation Late Effects Cohort (RLEC), formerly known as the Radiation Survivors Cohort, of rhesus (Macaca mulatta) non-human primates (NHPs) is a unique colony of long-term survivors of total-body irradiation (TBI). The cohort includes 212 live animals, with 17% being …

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Male mice treated with combined anti-fibrotic therapeutics, IPW5371 and tadalafil, are predisposed to adverse cardiovascular events

Jazz Q. Stephens, Uriel Blas‐Machado, Chrissy Sherrill, David L. Caudell et autres

Fibrosis is a pathological process with few therapeutic options. Experimental molecules are being developed to counteract the fibrotic effects through TGFβ receptor inhibition. Additionally, phosphodiesterase 5 (PDE5) inhibitors also have anti-fibrotic effects; however, the mechanism of action remains unresolved. IPW5371 is an …

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Common scents? A review of potentially shared chemical signals in the order Carnivora

Holly Root‐Gutteridge, Nancy D. Kock, Madeleine Young, Andrew C. Gill et autres

Many animals transmit information in the form of chemical signals to modify behavior or induce physiological change in receivers. For some taxa, such as species in the order Carnivora, chemical signals are known to provide a critical mode of communication, although they …

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Epizootic Yersinia enterocolitica in captive African green monkeys (Chlorocebus aethiops sabaeus)

Gayathriy Balamayooran, Hannah Atkins, Rachel N. Andrews, Kristofer T. Michalson et autres

Yersinia enterocolitica is a Gram-negative bacterium that typical results in enterocolitis in humans and poses significant worldwide risks to public health. An outbreak of yersiniosis in the Vervet/African green monkey colony at the WFSM during the winter of 2015–2016 accounted for widespread …

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Quantitative Assessment and Comparative Analysis of Longitudinal Lung CT Scans of Chest-Irradiated Nonhuman Primates

Priyanka Thakur, John D. Olson, Gregory O. Dugan, John Daniel Bourland et autres

Computed tomography (CT) imaging has been used to diagnose radiation-induced lung injury for decades. However, histogram-based quantitative tools have rarely been applied to assess lung abnormality due to radiation-induced lung injury (RILI). Here, we used first-order summary statistics to derive and assess …

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Ferret acute lung injury model induced by repeated nebulized lipopolysaccharide administration

Oula Khoury, Cara Clouse, Malcolm K. McSwain, Jeffrey R. Applegate et autres

Inflammatory lung diseases affect millions of people worldwide. These diseases are caused by a number of factors such as pneumonia, sepsis, trauma, and inhalation of toxins. Pulmonary function testing (PFT) is a valuable functional methodology for better understanding mechanisms of lung disease, …

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Total-Body Irradiation Is Associated With Increased Incidence of Mesenchymal Neoplasia in a Radiation Late Effects Cohort of Rhesus Macaques (Macaca mulatta)

W. Shane Sills, Janet Austin Tooze, John D. Olson, David L. Caudell et autres

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Dupuytren Cords Do Not Undergo Significant Histopathological Change After Collagenase Clostridium Histolyticum Injection

Meng Guo, Kai J. Yang, Nancy D. Kock, Roger A. Daley et autres

Background: Dupuytren disease creates thickened cords of the palmar fascia, leading to progressive flexion contractures that severely hinder hand function. Collagenase clostridium histolyticum (CCH) injection is a common, minimally invasive alternative to surgical excision of these cords. The impact of CCH injection …

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Clinicopathologic and Transcriptomic Analysis of Radiation-Induced Lung Injury in Nonhuman Primates

Priyanka Thakur, Ryne J. DeBo, Gregory O. Dugan, John Daniel Bourland et autres

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Inclusion of Flagellin during Vaccination against Influenza Enhances Recall Responses in Nonhuman Primate Neonates

Beth C. Holbrook, Sarah L. Hayward, Matthew J. Jorgensen, Lance K. Blevins et autres

ABSTRACT Influenza virus can cause life-threatening infections in neonates and young infants. Although vaccination is a major countermeasure against influenza, current vaccines are not approved for use in infants less than 6 months of age, in part due to the weak immune …

Hyperglucosuria induced by dapagliflozin augments bacterial colonization in the murine urinary tract

Panatda Saenkham, Jamie E. Jennings‐Gee, Braden S. Hanson, Nancy D. Kock et autres

AIM: To test the effects of dapagliflozin-induced hyperglucosuria on ascending bacterial urinary tract infection (UTI) in a mouse model. METHODS: Dapagliflozin or canagliflozin was used to induce hyperglucosuria in non-diabetic adult female mice prior to transurethral inoculation with uropathogenic Escherichia coli (UPEC) …

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Author response for "Hyperglucosuria Induced by Dapagliflozin Augments Bacterial Colonization in the Murine Urinary Tract"

Panatda Saenkham, Jamie E. Jennings‐Gee, Braden S. Hanson, Nancy D. Kock et autres