John Stoves

The electronic frailty index indicates mortality risk in end stage kidney disease patients on haemodialysis: retrospective survival analyses using linked data from two sources

Samuel D. Relton, Jenny Hewison, Zoe Rogers, Usha Appalsawmy et autres

Background: Over the last 30 years, with increasing comorbidity and frailty among people with end-stage kidney disease, there is recognition that dialysis may carry little benefit in some patient groups. We examined the utility of the electronic frailty index (eFI), modelling the …

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Biomarker Prediction of Delayed Graft Function and Prognosis Post–Kidney Transplantation

Rosamonde E. Banks, Michelle Wilson, Matthew Welberry Smith, Andrew Lewington et autres

Introduction: Aminoacylase-1 (ACY1) and additional biomarkers were evaluated for prediction of delayed graft function (DGF) and prognosis following kidney transplantation. Methods: Serum biomarkers were measured (days 1-2 posttransplant for DGF prediction and 1-3 for prognosis) in 237 patients transplanted in Leeds (2003-2011) …

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#410 Trying to reduce unnecessary carbon in haemodialysis (TRUNC-HD) — a regional sustainability quality improvement project

Stephanie Choo, Leeanne Lockley, John Stoves, Laura Chase et autres

Abstract Background and Aims Healthcare contributes 4–5% of global carbon dioxide equivalent (CO2e) emissions. Haemodialysis (HD) contributes disproportionately to this due to its resource-intensive nature. Dialysis services in Yorkshire launched Trying to Reduce UnNecessary Carbon in Haemodialysis (TRUNC-HD), a regional quality improvement …

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Sustainable health care in a renal centre - carbon saving is coupled with cost-efficiency

Gareth Murcutt, Ingeborg Steinbach, John Stoves

BACKGROUND: Healthcare contributes significantly to global carbon dioxide equivalent emissions, with kidney care contributing disproportionately to this. Renal medicine was one of the first specialities to actively develop a "green" community. This paper is a retrospective review of a series of comprehensive …

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Decisional Needs of People From Minority Ethnic Groups Around Living Donor Kidney Transplantation: A UK Healthcare Professionals’ Perspective

Ahmed Ahmed, Anna Winterbottom, Shenaz Ahmed, John Stoves et autres

Despite improved patient and clinical outcomes, living donor kidney transplantation is underutilized in the United Kingdom, particularly among minority ethnic groups, compared to deceased donor kidney transplantation. This may in part be due to the way in which kidney services present information …

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Optimized immunosuppression to prevent graft failure in renal transplant recipients with HLA antibodies (OuTSMART): a randomised controlled trial

Dominic Stringer, Leanne M. Gardner, Olivia Shaw, Brendan Clarke et autres

Background: 3% of kidney transplant recipients return to dialysis annually upon allograft failure. Development of antibodies (Ab) against human leukocyte antigens (HLA) is a validated prognostic biomarker of allograft failure. We tested whether screening for HLA Ab, combined with an intervention to …

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Patient information about living donor kidney transplantation across UK renal units: A critical review

Anna Winterbottom, John Stoves, Shenaz Ahmed, Ahmed Ahmed et autres

BACKGROUND: Patient information about living donor kidney transplantation is used to supplement conversations between health professionals, people with advanced kidney disease and potential kidney donors. It is not known if the information is designed to support decision-making about renal replacement options and …

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Facilitators and barriers to living donor kidney transplantation

Anna Winterbottom, Ahmed Ahmed, John Stoves, Shenaz Ahmed et autres

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Factors Impacting Conversations with Friends and Family about Living Kidney Donation

Ahmed Ahmed, Anna Winterbottom, John Stoves, Shenaz Ahmed et autres

Introduction Living donor kidney transplantation is the optimal modality of renal replacement therapy for advanced kidney disease. It is associated with superior recipient and graft survival, a better quality of life and self-reported health status compared to dialysis. Living kidney donation occurs …

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Barriers and enablers to the implementation of a complex quality improvement intervention for acute kidney injury: A qualitative evaluation of stakeholder perceptions of the Tackling AKI study

Laura Lamming, Eileen McDonach, Mohammed A. Mohammed, John Stoves et autres

BACKGROUND: Acute kidney injury in hospital patients is common and associated with reduced survival and higher healthcare costs. The Tackling Acute Kidney Injury (TAKI) quality improvement project aimed to reduce mortality rates in patients with acute kidney injury by implementing a multicomponent …

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Update to the study protocol, including statistical analysis plan, for the multicentre, randomised controlled OuTSMART trial: a combined screening/treatment programme to prevent premature failure of renal transplants due to chronic rejection in patients with HLA antibodies

Dominic Stringer, Leanne M. Gardner, Janet L. Peacock, Irene Rebollo‐Mesa et autres

BACKGROUND: Chronic rejection is the single biggest cause of premature kidney graft failure. HLA antibodies (Ab) are an established prognostic biomarker for premature graft failure so there is a need to test whether treatment decisions based on the presence of the biomarker …

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An Organizational-Level Program of Intervention for AKI: A Pragmatic Stepped Wedge Cluster Randomized Trial

Nicholas M. Selby, Anna Casula, Laura Lamming, John Stoves et autres

Significance Statement National and international guidelines recommend supportive approaches to AKI management, but organizational strategies to improve delivery of AKI care have not previously been tested in multicenter randomized studies. The authors describe a pragmatic, multicenter, cluster randomized trial across five United …

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