Kenneth S. Bell

Bacterial Human Pathogen Genomes: an Overview

Stephen John Bentley, Mohammed Sebaihia, Nicholas Robert Thomson, Matthew T. G. Holden et autres

This chapter provides an overview of what has been learned from analysis of bacterial human pathogen genomes. Bacterial human pathogens such as alphaproteobacteria, spirochetes, actinobacteria, firmicutes and gammaproteobacteria are studied. Haemophilus influenzae is a common commensal of the human respiratory tract. Three …

The plant formin AtFH4 interacts with both actin and microtubules, and contains a newly identified microtubule-binding domain

Michael J. Deeks, Matyáš Fendrych, Andrei P. Smertenko, Kenneth S. Bell et autres

The dynamic behaviour of the actin cytoskeleton in plants relies on the coordinated action of several classes of actin-binding proteins (ABPs). These ABPs include the plant-specific subfamilies of actin-nucleating formin proteins. The model plant species Arabidopsis thaliana has over 20 formin proteins, …

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The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation

Nicholas Robert Thomson, Corin Yeats, Kenneth S. Bell, Matthew T. G. Holden et autres

The obligate intracellular bacterial pathogen Chlamydophila abortus strain S26/3 (formerly the abortion subtype of Chlamydia psittaci) is an important cause of late gestation abortions in ruminants and pigs. Furthermore, although relatively rare, zoonotic infection can result in acute illness and miscarriage in …

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Identification of a New Quorum-Sensing-Controlled Virulence Factor in Erwinia carotovora subsp. atroseptica Secreted via the Type II Targeting Pathway

Mark J. Corbett, Sam Virtue, Kenneth S. Bell, Paul R. J. Birch et autres

Two-dimensional polyacrylamide gel electrophoresis of the secreted proteins of Erwinia carotovora subsp. atroseptica revealed a low-abundance protein that was identified by mass spectrometry as a homologue of a Xanthomonas campestris avirulence protein with unknown function. The predicted Svx protein has an N-terminal …

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Use of a Pooled Transposon Mutation Grid to Demonstrate Roles in Disease Development for Erwinia carotovora subsp. atroseptica Putative Type III Secreted Effector (DspE/A) and Helper (HrpN) Proteins

Maria C. Holeva, Kenneth S. Bell, Lizbeth J. Hyman, Anna O. Avrova et autres

Soft rot Erwinia spp., like other closely related plant pathogens, possess a type III secretion system (TTSS) (encoded by the hrp gene cluster) implicated in disease development. We report the sequence of the entire hrp gene cluster and adjacent dsp genes in …

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Soft rot erwiniae: from genes to genomes

Ian K. Toth, Kenneth S. Bell, Maria C. Holeva, Paul R. J. Birch

UNLABELLED: SUMMARY The soft rot erwiniae, Erwinia carotovora ssp. atroseptica (Eca), E. carotovora ssp. carotovora (Ecc) and E. chrysanthemi (Ech) are major bacterial pathogens of potato and other crops world-wide. We currently understand much about how these bacteria attack plants and protect …

Sample sequencing of a selected region of the genome of Erwinia carotovora subsp. atroseptica reveals candidate phytopathogenicity genes and allows comparison with Escherichia coli The GenBank accession numbers for the 424 sequences determined in this work are BH614193 to BH614616.

Kenneth S. Bell, Anna O. Avrova, Maria C. Holeva, Linda Cardle et autres

Genome sequencing is making a profound impact on microbiology. Currently, however, only one plant pathogen genome sequence is publicly available and no genome-sequencing project has been initiated for any species of the genus Erwinia, which includes several important plant pathogens. This paper …

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Detection and Quantification of Spongospora subterranea f. sp. subterranea in Soils and on Tubers Using Specific PCR Primers

Kenneth S. Bell, Jane Roberts, Susan R. Verrall, Daniel W. Cullen et autres