Dannis G van Vuurden

Bridging Borders in Pediatric Oncology: Cross-Regional Insights into Physical Exercise Program Perceptions in Europe, North Africa, and Arab Countries

Elwira Szychot, Jan-Marius Wedig, Kyra Druivenga, Moatasem El-Ayadi et autres

Abstract Structured physical exercise programs (PEPs) in pediatric oncology have shown benefits for physical, psychosocial, and cognitive outcomes, yet their integration into routine care varies globally. This study explores health care professionals' perceptions of PEPs across European, North African, and Arab pediatric …

gb, pl, de, Égypte, at, it, jo, Maroc, sa, es, nl, ch, us (code pays fourni par la source)

Multimodal analysis of pediatric pilocytic astrocytomas reveals tumor location-associated cellular and transcriptional heterogeneity

Julie A S Lammers, Jacob S Rozowsky, Friso Calkoen, Thijs J M van den Broek et autres

BACKGROUND: Pilocytic astrocytomas (PAs) are the most common pediatric central nervous system tumors, which present with limited genetic but significant clinical heterogeneity. Current treatment strategies are partly effective, but tumors often progress, and patients experience long-term side effects, highlighting the need for …

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Long-term survival and cure fraction estimates for paediatric central nervous system tumours in 31 European countries (EUROCARE-6): a population-based study

Raoull Hoogendijk, Riccardo Capocaccia, Jasper van der Lugt, Mariëtte E.G. Kranendonk et autres

nl, it (code pays fourni par la source)

Single-cell spatial analysis of pediatric high-grade glioma reveals a novel population of SPP1+/GPNMB+ myeloid cells with immunosuppressive and tumor-promoting capabilities

Thijs J M van den Broek, Raoull Hoogendijk, Mariëtte E.G. Kranendonk, Julie A S Lammers et autres

Abstract Background Pediatric-type diffuse high-grade gliomas (pHGGs) are a leading cause of pediatric cancer-related mortality. Although immunotherapy offers a promising treatment avenue, clinical responses in pHGG patients remain limited. A detailed understanding of the tumor immune microenvironment (TIME) is essential for advancing …

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Drug delivery strategies to cross the blood-brain barrier in Alzheimer’s disease: a comprehensive review on three promising strategies

Lotte A. de Koning, Daniel Aaron Vazquez-Matias, Wissam Beaino, Daniëlle J. Vugts et autres

The field of Alzheimer’s disease (AD) drug development is rapidly changing, with two anti-amyloid monoclonal antibodies (mAbs) having received Food and Drug Administration (FDA) approval, additionally many compounds are in the pipeline. A major obstacle for novel AD therapeutics is the blood-brain …

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Gross tumor volume increase and need for adaptive radiotherapy in pediatric-type diffuse high-grade glioma of the midline structures

Fasco van Ommen, Toon Van Genechten, Mirjam E. Willemsen-Bosman, Max Peters et autres

INTRODUCTION: Current pediatric-type diffuse high-grade glioma radiotherapy protocols apply a 1.0 cm clinical target volume (CTV) margin around the gross tumor volume (GTV). However, in adults with glioblastoma, large variations in GTV are observed during radiotherapy. The study aimed to map the …

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DIPG-33. CHARACTERIZING THE NEURO-VASCULAR UNIT IN DIFFUSE INTRINSIC PONTINE GLIOMA

Fatma E. El‐Khouly, Rianne Haumann, Marjolein Breur, Sophie E. M. Veldhuijzen van Zanten et autres

Abstract Diffuse intrinsic pontine glioma (DIPG) is a childhood brainstem tumor with a median overall survival of eleven months. Lack of chemotherapy efficacy may be related to an intact blood-brain-barrier (BBB). In this study we aim to compare the neuro-vascular unit (NVU) …

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MRI changes in time after cranial irradiation, and their relation with pituitary function in survivors of childhood medulloblastoma

C. Van Ommen, Laura van Iersel, MH Lequin, SC Clement et autres

Adaptive behavior impaired in children with low‐grade glioma

Heleen Maurice‐Stam, Jan Pieter Marchal, Dannis G van Vuurden, William Peter Vandertop et autres

BACKGROUND: Adaptive behavior, i.e., the performance on daily activities required for personal and social independence, is essential to estimate in children with low-grade glioma (LGG) since most of them are long-term survivors. Our aim was to investigate adaptive behavior in children with …

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Biological material collection to advance translational research and treatment of children with CNS tumours: position paper from the SIOPE Brain Tumour Group

Stefan Rutkowski, Piergiorgio Modena, Daniel S. Williamson, Kornelius Kerl et autres

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NanoSonoChemotherapy for Diffuse Intrinsic Pontine Glioma (NSC4DIPG)

Chrit T.W. Moonen, Dannis G van Vuurden

Effective Drug Delivery in Diffuse Intrinsic Pontine Glioma: A Theoretical Model to Identify Potential Candidates

Fatma E. El‐Khouly, Dannis G van Vuurden, Thom Stroink, Esther Hulleman et autres

Despite decades of clinical trials for diffuse intrinsic pontine glioma (DIPG), patient survival does not exceed 10% at two years post-diagnosis. Lack of benefit from systemic chemotherapy may be attributed to an intact blood-brain-barrier (BBB). We aim to develop a theoretical model …

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