R. A. A. Maes

The Neurotoxicity and Pharmacokinetics of Oral Ifosfamide

Martin Highley, Guido Momerency, Diane Sawyers, E. A. de Bruijn et autres

Purpose:Ifosfamide can cause an unexplained encephalopathy. The incidence after intravenous infusion is 10%, but is much higher after oral administration. This study assesses the pharmacokinetics of oral ifosfamide in relation to neurotoxicity. Patients and Methods:Eleven patients received oral ifosfamide 500 mg twice …

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Concentration of Thiamphenicol in the Human Prostate and Testis

T. A. Plomp, K Schalkhäuser, R. A. A. Maes

The concentration of thiamphenicol in prostatic tissue, testicular tissue and serum after a single intravenous injection of 1 g thiamphenicol glycinate ester was investigated. The prostatic and testicular specimens were obtained by prostatectomy and plastic orchidectomy, respectively, from patients with adenomas and …

Docetaxel and gemcitabine combination therapy in advanced transitional cell carcinoma of the urothelium: results of a phase II and pharmacologic study

Herlinde Dumez, Marc Martens, Johan Selleslach, G. Guetens et autres

Our objective was to determine the response to gemcitabine plus docetaxel in advanced urothelial transitional cell carcinoma in a phase II trial, and gemcitabine distribution between plasma and erythrocytes, following docetaxel administration. Patients with locally advanced or metastatic transitional cell carcinoma, following …

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Recent applications of liquid chromatography–mass spectrometry in forensic science

Michelle Wood, Marleen Laloup, Nele Samyn, María del Mar Ramírez Fernández et autres

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A phase I dose-finding clinical pharmacokinetic study of an oral formulation of irinotecan (CPT-11) administered for 5 days every 3 weeks in patients with advanced solid tumours

Herlinde Dumez, Ahmad Awada, Martine Piccart, Sylvie Assadourian et autres

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In vitro partition of docetaxel and gemcitabine in human volunteer blood: the influence of concentration and gender

Herlinde Dumez, Gunther Guetens, Gert De Boeck, Martin Highley et autres

We have performed in vitro incubations of blood from male and female volunteers with gemcitabine and docetaxel alone, and in combination, at different concentration gradients in order to investigate changes in partition between red blood cells (RBCs), total plasma and the free …

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In vitro partition of irinotecan (CPT-11) in human volunteer blood: the influence of concentration, gender and smoking

Herlinde Dumez, Gunther Guetens, Gert De Boeck, Martin Highley et autres

We have performed in vitro incubations of blood from male and female volunteers, smokers and non-smokers, with irinotecan at a gradient of different concentrations in order to investigate changes of partition between red blood cells (RBCs), total plasma and the free fraction. …

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Simultaneous analysis of gamma-hydroxybutyric acid and its precursors in urine using liquid chromatography–tandem mass spectrometry

Michelle Wood, Marleen Laloup, Nele Samyn, Michael Morris et autres

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The relevance of therapeutic drug monitoring in plasma and erythrocytes in anti-cancer drug treatment

Herlinde Dumez, Gunther Guetens, Gert De Boeck, Martin Highley et autres

Therapeutic drug monitoring generally focuses on the plasma compartment only. Differentiation between the total plasma concentration and the free fraction (plasma water) has been described for a number of limited drugs. Besides the plasma compartment, blood has also a cellular fraction which …

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Development of a Rapid and Sensitive Method for the Quantitation of Benzodiazepines in Calliphora vicina Larvae and Puparia by LC-MS-MS

Michelle Wood, Marleen Laloup, Karen Pien, Nele Samyn et autres

Liquid chromatography-tandem mass spectrometry (LC-MS-MS) is emerging as the tool of choice for rapid analysis and the detection of biologically active compounds in complex mixtures. We describe the development of a sensitive method for the simultaneous quantitation of 10 benzodiazepines in Calliphora …

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Amount of self-reported illicit drug use compared to quantitative hair test results in community-recruited young drug users in Amsterdam

E Welp, Ingrid J. Bosman, Miranda Langendam, M Totté et autres

AIMS: To assess the dose-effect relationship between self-reported drug intake and the concentration of drugs and/or their metabolites in hair and to examine factors that may mediate this relationship. DESIGN AND SETTING: A cohort study among young drug users (YDU) in Amsterdam, …

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Operant learning and differential-reinforcement-of-low-rate 36-s responding in 5-HT1A and 5-HT1B receptor knockout mice

Tommy Pattij, Laus M. Broersen, Judith van der Linde, Lucianne Groenink et autres

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