Yukiko Ota

In Older Men With Persistent Nocturia Due to Nocturnal Polyuria, Desmopressin Is Effective for Those With Higher Muscle Mass

Keisuke Ishikawa, Akira Tsujimura, Riho Kasai, Yukiko Ota et autres

OBJECTIVES: To investigate the efficacy of desmopressin in older men with persistent nocturia due to nocturnal polyuria and then determine the independent factors affecting the efficacy of desmopressin. METHODS: Desmopressin 50 mg was administered for 12 weeks to 49 patients (76.3 ± …

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Removal of volatile organic compounds by chemical filters significantly inhibited the development of atopic dermatitis symptoms in mice: potential implications for air-conditioning systems in healthcare environments

Chiharu Ohira, Kengo Tomita, Yukiko Ota, Keiichi Yano et autres

Volatile organic compounds (VOCs) are increasingly implicated in systemic diseases, but their contribution to skin disorders such as atopic dermatitis (AD) remains unclear. This study assessed VOC concentrations in medical environments, their effects on AD development, and the efficacy of VOC removal …

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Dehydroepiandrosterone Sulfate/Cortisol Ratio as a Biomarker of Depressive Symptoms in Late-Onset Hypogonadism: An Analysis of 3,005 Males

Haruhiko Wakita, Ryutaro Kasai, Yukiko Ota, Takashi Kanda et autres

PURPOSE: Depressive symptoms related to late-onset hypogonadism (LOH) have attracted attention due to their impact on absenteeism and presenteeism. Although LOH symptoms are not consistently associated with serum testosterone levels, elevated cortisol and decreased dehydroepiandrosterone sulfate (DHEA-S) are frequently observed in depressed …

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Indoor VOC Filtration Mitigates Pulmonary Inflammation in Murine Models of Allergic Asthma and LPS‐Induced Acute Lung Injury

Kengo Tomita, Chiharu Ohira, Mao Kaneki, Yukiko Ota et autres

Indoor volatile organic compounds (VOCs) are ubiquitous and often within guideline ranges, yet their impact on allergic lung disease and pharmacologic responses remains unclear. We tested whether lowering VOCs attenuates lung inflammation and modifies antihistamine efficacy in murine asthma and acute lung …

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Efficacy and Safety of Clomiphene Citrate for Late‐Onset Hypogonadism as Evaluated by Aging Male Symptom Rating Scale Over One Year

Yuta Anno, Akira Tsujimura, Yukiko Ota, Takashi Kanda et autres

OBJECTIVE: To evaluate the efficacy and safety of clomiphene citrate for late-onset hypogonadism by assessing changes in serum testosterone levels and Aging Males Symptoms scores over 1 year. MATERIALS AND METHODS: This retrospective study comprised 54 men (44.2 ± 0.9 years old) …

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Liver fibrosis is associated with men’s health care symptoms, especially erectile dysfunction and lower urinary tract symptoms

Yuka Uesaka, Akira Tsujimura, Ryutaro Kasai, Yukiko Ota et autres

PURPOSE: The prevalence of liver dysfunction among men has been steadily increasing in recent decades. Among the various non-invasive assessment tools available, the Fibrosis-4 (FIB-4) Index has emerged as a particularly valuable and widely adopted scoring system for evaluating liver fibrosis. This …

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Volatile organic compounds and ionic substances contamination in cell processing facilities during rest period; a preliminary assessment of exposure to cell processing operators

Mitsuru Mizuno, Kôki Abe, Takashi Kakimoto, Keiichi Yano et autres

Introduction: generated from peracetic acid, nitrogen oxides (NOx) and sulfur oxides (SOx) from outdoor environment are also known to pollute air. Therefore, our objective was to assess the air quality in CPFs and detect volatile organic compounds (VOCs) from disinfectants and building …

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SPARC promotes production of type IV and VII collagen and their skin basement membrane accumulation

Tomomi Nakamura, Hiroyuki Yoshida, Yukiko Ota, Yoko Endo et autres

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A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function

Yukiko Ota, Hiroyuki Yoshida, Yoko Endo, Tetsuya Sayo et autres

Hyaluronan (HA), an essential component of the extracellular matrix of the skin, is synthesized by HA synthases (HAS1-3). To date, epidermal HA has been considered a major player in regulating cell proliferation and differentiation. However, a previous study reported that depletion of …

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Antiwrinkle efficacy of 1‐ethyl‐β‐N‐acetylglucosaminide, an inducer of epidermal hyaluronan production

Yoko Endo, Hiroyuki Yoshida, Yumiko Akazawa, Kohei Yamazaki et autres

BACKGROUND: Hyaluronan (HA) has a unique hydration capacity that contributes to firmness and bounciness of the skin. Epidermal HA declines with skin aging, which may lead to clinical signs of aging including skin wrinkles and loss of hydration and elasticity. Recently, we …

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Accelerated human epidermal turnover driven by increased hyaluronan production

Yoko Endo, Hiroyuki Yoshida, Yukiko Ota, Yumiko Akazawa et autres

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Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17

Takuo Yuki, Megumi Tobiishi, Ayumi Kusaka-Kikushima, Yukiko Ota et autres

Tight junction (TJ) dysfunction in the stratum granulosum leads to aberrant barrier function of the stratum corneum (SC) in the epidermis. However, it is unclear whether TJs are perturbed in atopic dermatitis (AD), a representative aberrant SC-related skin disease, and whether some …

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