Carol L. Shields

Phenotypic expansion of retinal abnormalities in folliculin ( FLCN ) variant-related pathology (Birt–Hogg–Dubé syndrome)

Ari H. August, Carol L. Shields, Jasmine H. Francis, Fred K. Chen et autres

PURPOSE: Birt-Hogg-Dubé (BHD) syndrome 1 is caused by pathogenic folliculin (FLCN) variants, resulting in classic hair follicle tumors, pulmonary cysts, pneumothorax, and renal cancer. FLCN is expressed in retinal tissues, and previous reports of BHD described flecked chorioretinopathy, choroidal melanoma, chorioretinal atrophy, …

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LACK OF COMPLICATIONS OF HIGH-DOSE INTRAVITREAL TOPOTECAN FOR RECURRENT RETINOBLASTOMA IN 81 CONSECUTIVE INJECTIONS

Carol L. Shields, Robert Medina, Taweevat Attaseth, Sara E. Lally

PURPOSE: To explore the safety of high-dose intravitreal topotecan for recurrent retinoblastoma management in human eyes. METHODS: There were 81 consecutive injections of high-dose intravitreal topotecan (90 μ g/0.18 cc‒100 µ g/0.20 cc on a monthly basis) in 25 eyes with recurrent …

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Importance of Thickness When Evaluating Choroidal Tumors

Carol L. Shields

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Evolving trends in retinoblastoma management: A 16-year clinicopathological analysis of enucleated eyes

Ari H. August, Darcy Curtis, Maya Eiger‐Moscovich, Antonio Yaghy et autres

Abstract: PURPOSE: New treatments for advanced retinoblastoma (RB) have offered alternatives to primary enucleation. We assessed the impact of these therapies on the indications for enucleation and the histopathological findings in enucleated eyes with RB. MATERIALS AND METHODS: Eyes of all patients …

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The Role of Intravitreal Chemotherapy as an Adjunctive Treatment for Retinoblastoma: A Systematic Review and Single-Arm Meta-Analysis

Andrés Bravo-González, Pablo Domínguez-Ruiz, Marı́a Victoria González, Sara Hira et autres

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Novel Uveal Melanoma Patient-Derived Organoid Models Recapitulate Human Disease to Support Translational Research

Lauren A. Dalvin, Cynthia Andrews‐Pfannkoch, David R. Miley, Tara L. Hogenson et autres

Purpose: A lack of representative human disease models has limited the translation of new and more effective treatments in uveal melanoma (UM), the most common primary adult intraocular malignancy. To fill this critical need, we developed and characterized a multicenter biobank of …

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HIGH-DOSE INTRAVITREAL TOPOTECAN FOR RECURRENT RETINOBLASTOMA, SUBRETINAL SEEDS, AND VITREOUS SEEDS

Carol L. Shields, Robert Medina, Haley Evans, Nicole Valdes-Perez et autres

PURPOSE: To evaluate the efficacy and safety of high-dose intravitreal topotecan (IvitTopo) for recurrent retinoblastoma. METHODS: There were 13 patients with recurrent retinoblastoma treated with high-dose IvitTopo (90 micrograms [ μ g]/0.18cc-100 µ g/0.20cc). The primary outcome measures were tumor control, globe …

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Stalagmite iridopathy

Kunal Malik, Antonio Yaghy, Carol L. Shields

Case An 18-month-old African-American boy with 1-month history of left upper eyelid swelling and mild conjunctival injection was noted to have an iris lesion in the left eye (OS). On examination, visual acuity was fix-and-follow in both eyes (OU). Intraocular pressures were …

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Incontinentia pigmenti presenting as pseudoretinoblastoma

Samuel Martin, Ayan Chatterjee, Antonio Yaghy, Carol L. Shields

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Ophthalmic Manifestations of Rosai-Dorfman Disease in Five Patients

Babak Masoomian, Sara E. Lally, Jerry A. Shields, Carol L. Shields

Purpose: To report clinical features, pathology characteristics, and treatment outcomes of five patients with Rosai-Dorfman disease (RDD). Methods: A retrospective case series of patients with RDD from the Ocular Oncology Service of Wills Eye Hospital between 1974 and 2018. Results: There were …

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Transient increased exudation after photodynamic therapy of intraocular tumors

Arman Mashayekhi, Carol L. Shields, Jerry A. Shields

To report transient increased exudation after photodynamic therapy (PDT) of three different intraocular tumors (retinal hemangioblastoma, retinal astrocytoma, amelanotic choroidal melanoma). PDT with verteporfin (6 mg/m(2) body surface area) was delivered at a dose of 50 J/cm(2) and intensity of 600 mW/cm(2) …

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Peripheral Exudative Hemorrhagic Chorioretinopathy: A Variant of Polypoidal Choroidal Vasculopathy?

Arman Mashayekhi, Carol L. Shields, Jerry A Shields

Purpose: To report a case of peripheral exudative hemorrhagic chorioretinopathy (PEHCR) in an elderly patient. Case Report: A 74-year-old Caucasian woman, with a 20-year history of a stable choroidal nevus in her right eye, was referred for evaluation of two small hemorrhagic …