James S. Milledge

Physiological responses during ascent to high altitude and the incidence of acute mountain sickness

Alexandra Cobb, Denny Z H Levett, Kay Mitchell, W Aveling et autres

Acute mountain sickness (AMS) occurs when there is failure of acclimatisation to high altitude. The aim of this study was to describe the relationship between physiological variables and the incidence of AMS during ascent to 5300 m. A total of 332 lowland-dwelling …

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Hypobaric Hypoxia: Adaptation and Acclimatization

John H. Coote, James S. Milledge

The adverse effects of hypoxia on the nervous system are experienced at relatively low altitudes, and the severity increases from that experienced by aircrew in the mild hypoxic environment of the cabins of commercial transport aircraft to that experienced by mountaineers and …

Benzolamide improves oxygenation and reduces acute mountain sickness during a high‐altitude trek and has fewer side effects than acetazolamide at sea level

David Collier, Chris B. Wolff, A Hedges, John E Nathan et autres

Acetazolamide is the standard carbonic anhydrase (CA) inhibitor used for acute mountain sickness (AMS), however some of its undesirable effects are related to intracellular penetrance into many tissues, including across the blood-brain barrier. Benzolamide is a much more hydrophilic inhibitor, which nonetheless …

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Stanhope Speer, Physician and Alpinist: In 1853, First to Describe Mountain Sickness?

James S. Milledge

In 1853, Stanhope Templeman Speer published a two-part paper in The Association Medical Journal on Mountain Sickness. Speer was a physician who had worked at the Brompton Hospital for Chest Diseases in London and had been Professor of Medicine in Dublin. He …

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King of the Mountains: Tibetan and Sherpa Physiological Adaptations for Life at High Altitude

Edward T. Gilbert-Kawai, James S. Milledge, Michael P. W. Grocott, DANIEL S. MARTIN

Anecdotal evidence surrounding Tibetans' and Sherpas' exceptional tolerance to hypobaric hypoxia has been recorded since the beginning of high-altitude exploration. These populations have successfully lived and reproduced at high altitude for hundreds of generations with hypoxia as a constant evolutionary pressure. Consequently, …

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Workload during cardiopulmonary resuscitation

Thomas Küpper, Juergen Steffgen, Andrew Paul Morrison, James S. Milledge et autres

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Should Sleep Quality Be Part of the Lake Louise Acute Mountain Sickness Score?

James S. Milledge

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High Altitude Medicine and Physiology 5E

John B. West, Robert B. Schoene, Andrew M. Luks, James S. Milledge

A comprehensive update to this preeminent and accessible text, this fifth edition of a bestseller was developed as a response to man's attempts to climb unaided to higher altitudes and to spend more time in these conditions for both work and recreation. …

Career perspective: Jim Milledge

James S. Milledge

This paper is an overview of my career as a hospital physician with special interest in respiratory diseases. Alongside this career, I have been fortunate to be able to pursue my professional hobby of high altitude medicine and physiology, partly in the …

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The Silver Hut Expedition, 1960–1961

James S. Milledge

The 1960-1961 Himalayan Scientific and Mountaineering Expedition, commonly known as the Silver Hut Expedition, was a unique project to study the physiology of acclimatization in human lowlander subjects at extreme altitude over a prolonged period and also to make an attempt on …

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Sukhamay Lahiri, 1933–2009

James S. Milledge

25th Anniversary of Research in High Altitude Physiology and Medicine at the New Capanna Margherita, October 9–11, 2008, Varallo, Italy

James S. Milledge