Boris Labar

Red Cell Pyruvate Kinase in Acute Leukemia

Boris Labar, Ana Stavljenić, L Jusufhodzić

The red cell pyruvate kinase (PK) activity, KM for phosphoenolpyruvate (PEP) and adenosine diphosphate (ADP), and thermostability properties were studied in patients with acute leukemias. The acquired PK defect was found in patients with acute myeloid leukemia, while it was normal in …

Venous thromboembolism in Croatia – Croatian Cooperative Group for Hematologic Diseases (CROHEM) study

Dražen Pulanić, Velka Gverić‐Krečak, Zlatka Nemet-Lojan, Hrvoje Holik et autres

AIM: To analyze the incidence and characteristics of venous thromboembolism (VTE) in Croatia. METHODS: The Croatian Cooperative Group for Hematologic Diseases conducted an observational non-interventional study in 2011. Medical records of patients with newly diagnosed VTE hospitalized in general hospitals in 4 …

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Prognostic significance of constitutive phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase phosphorylation in acute myeloid leukemia

Sanja Prijić, Ivo Ugrina, Boris Labar, Damir Nemet et autres

Acute myeloid leukemia (AML) is a malignant hematopoietic disease with poor clinical course and outcome. There is a constant need for new prognostic factors that could facilitate patient risk stratification. The aim of our research was to determine the phosphorylation levels of …

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Parameters detected by geriatric and quality of life assessment in 195 older patients with myelodysplastic syndromes and acute myeloid leukemia are highly predictive for outcome

Barbara Deschler-Baier, Gabriele Ihorst, U. Platzbecker, Ulrich Germing et autres

Myelodysplastic syndromes and acute myeloid leukemia exemplify the complexity of treatment allocation in older patients as options range from best supportive care, non-intensive treatment (e.g. hypomethylating agents) to intensive chemotherapy/hematopoietic cell transplantation. Novel metrics for non-disease variables are urgently needed to help …

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Erratum

Sung Yong Oh, Won Seog Kim, Jin Seok Kim, Seok Jin Kim et autres

Erratum

Sung Yong Oh, Won Seog Kim, Jin Seok Kim, Seok Jin Kim et autres

Aberantni imunofenotipovi u prognozi akutne mijeloične leukemije

Mirta Mikulić, Vedran Hostić, Drago Batinić, Ranka Serventi‐Seiwerth et autres

Sažetak.Cilj: Dijagnoza akutne mijeloične leukemije (AML) temelji se na nalazu citomorfologije, imunofenotipizacije i citogenetike.Osnovna uloga imunofenotipizacije jest određivanje krvne loze te prepoznavanje aberantnih fenotipova.U ovom članku određena je učestalost i prognostička vrijednost aberantnih fenotipova u bolesnika s AML-om.Metode: U retrospektivnom istraživanju prikupljeni …

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Dasatinib u liječenju Ph+ KML-a – zagrebačko iskustvo

Dubravka Sertić, S Davidović, Renata Zadro, Igor Aurer et autres

Sažetak.Cilj: U radu su prikazani rezultati liječenja dasatinibom u bolesnika s Philadelphia pozitivnom kroničnom mijeloičnom leukemijom koji su prethodno liječeni imatinibom ili su bili u uznapredovanoj fazi bolesti.Metode: Od 11 bolesnika s Ph+ KML-om, u 8 njih u kroničnoj fazi bolesti dasatinib …

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High Dose (HD-AraC) Vs Standard Dose Cytosine Arabinoside (SD-AraC) During Induction and IL-2 Vs Observation After Consolidation/Autologous Stem Cell Transplantation in Patients with Acute Myelogenous Leukemia (AML): Final Report of the AML-12 Trial of EORTC and GIMEMA Leukemia Groups on the Value of Low Dose IL-2 Maintenance,

Roelof Willemze, Stefan Suciu, F Mandelli, Stijn J.M. Halkes et autres

Abstract Abstract 3612 The AML-12 randomized phase III trial of the EORTC and GIMEMA Leukemia Groups assessed the efficacy and toxicity of HD-AraC (3 g/sqm/12 hrs for 4 days) combined with daunorubicin (50 mg/sqm/d for 3 days) and etoposide (50 mg/sqm/d for …

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Ikaros transcription factors expression in cell differentiation

Mladen Paradžik, Maja Matulić, Drago Batinić, Boris Labar et autres

Ikaros, Aiolos, and Helios are transcription factors important in lymphocyte differentiation and development. One of the most interesting aspects of the Ikaros family members is that they are expressed as multiple splice variants and proteins arising from alternatively spliced transcripts may act …

An outbreak of Malassezia in patients with hematologic malignances

Marija Jandrlić, Boris Labar, Damir Nemet, Smilja Kalenić et autres

Malassezia je prepoznata kao novi bolnicki patogen u novorođencadi i imunokompromitiranih bolesnika. Zastitnom izolacijom hematoloskih bolesnika sprecava se prijenos infekcija putem kontakta, hrane, vode, zraka i nežive bolnicke okoline. U radu je prikazan tijek epidemije uzrokovane Malassezia na odjelu za hematologiju, kao …

Ikaros and Notch transcription factors in lymphocyte differentiation

Mladen Paradžik, Maja Matulić, Drago Batinić, Boris Labar et autres