Su-Mei Cao

A large-scale population-based study reveals that gp42-IgG antibody is protective against EBV–associated nasopharyngeal carcinoma

Xiang‐Wei Kong, Guo‐Long Bu, Hua Chen, Yu-Hua Huang et autres

BACKGROUNDEBV is associated with nasopharyngeal carcinoma (NPC), but the existence of a NPC protective antibody against EBV-associated antigens remains unclear.METHODSPatients with NPC and matched controls were identified from prospective cohorts comprising 75,481 participants in southern China. ELISA and conditional logistic regression were …

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Highly sensitive detection platform-based diagnosis of oesophageal squamous cell carcinoma in China: a multicentre, case–control, diagnostic study

Yu Wang, Shan Xing, Yi‐Wei Xu, Qingxia Xu et autres

BACKGROUND: Early detection and screening of oesophageal squamous cell carcinoma rely on upper gastrointestinal endoscopy, which is not feasible for population-wide implementation. Tumour marker-based blood tests offer a potential alternative. However, the sensitivity of current clinical protein detection technologies is inadequate for …

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Multilaboratory Assessment of Epstein-Barr Virus Serologic Assays: the Case for Standardization

Zhiwei Liu, Kelly J. Yu, Anna E. Coghill, Nicole Brenner et autres

IgA antibodies targeting Epstein-Barr virus (EBV) have been proposed for screening for nasopharyngeal carcinoma (NPC). However, methods differ, and the antigens used in these assays differ considerably between laboratories. To enable formal comparisons across a range of established EBV serology assays, we …

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Induction chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: long-term results of a phase III multicentre randomised controlled trial

Qi Yang, Su-Mei Cao, Ling Guo, Yi-Jun Hua et autres

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Genome sequencing analysis identifies Epstein–Barr virus subtypes associated with high risk of nasopharyngeal carcinoma

Miao Xu, Youyuan Yao, Hui Chen, Shanshan Zhang et autres

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Past and Recent Salted Fish and Preserved Food Intakes Are Weakly Associated with Nasopharyngeal Carcinoma Risk in Adults in Southern China

Donal Barrett, Alexander Ploner, Ellen T. Chang, Zhiwei Liu et autres

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Reproductive history and risk of nasopharyngeal carcinoma: A population-based case–control study in southern China

Ruimei Feng, Ellen T. Chang, Zhiwei Liu, Qing Liu et autres

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Association Between Environmental Factors and Oral Epstein-Barr Virus DNA Loads: A Multicenter Cross-sectional Study in China

Yong-Qiao He, Xiaoyu Liao, Wen-Qiong Xue, Ya-Fei Xu et autres

Background: Oral Epstein-Barr virus (EBV) status reflects host EBV activity and potentially links to EBV-associated diseases, however, factors influencing oral EBV loads or reactivation, such as environmental exposures or host factors, are not fully understood. Methods: A 2-stage, multicenter, cross-sectional study of …

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Medical History, Medication Use, and Risk of Nasopharyngeal Carcinoma

Xiling Xiao, Zhe Zhang, Ellen T. Chang, Zhiwei Liu et autres

Because persistent inflammation may render the nasopharyngeal mucosa susceptible to carcinogenesis, chronic ear-nose-throat (ENT) disease and its treatment might influence the risk of nasopharyngeal carcinoma (NPC). Existing evidence is, however, inconclusive and often based on methodologically suboptimal epidemiologic studies. In a population-based …

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The Relationship Between Environmental Factors and the Profile of Epstein-Barr Virus Antibodies in the Lytic and Latent Infection Periods in Healthy Populations from Endemic and Non-Endemic Nasopharyngeal Carcinoma Areas in China

Yong-Qiao He, Wen-Qiong Xue, Feng-Hua Xu, Ya-Fei Xu et autres

Our previous study found that smoking was associated with an elevated level of the antibody against VCA in the Epstein-Barr virus (EBV) lytic phase, which was an important predictive marker of the risk of nasopharyngeal carcinoma (NPC). It remained unknown whether environmental …

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Development of a population-based cancer case-control study in southern china

Weimin Ye, Ellen T. Chang, Zhiwei Liu, Qing Liu et autres

// Weimin Ye 1 , Ellen T. Chang 2, 3 , Zhiwei Liu 1 , Qing Liu 4, 5 , Yonglin Cai 6, 7 , Zhe Zhang 8, 9 , Guomin Chen 10 , Qi-Hong Huang 11 , Shang-Hang Xie 4, 5 …

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Evaluation of seven recombinant VCA-IgA ELISA kits for the diagnosis of nasopharyngeal carcinoma in China: a case–control trial

Rui Gao, Lin Wang, Qing Liu, Li‐Fang Zhang et autres

OBJECTIVE: Seven recombinant viral capsid antigen-IgA (VCA-IgA) ELISA kits are widely used in China, but their diagnostic effects have not been evaluated. In this study, we evaluated whether the diagnostic effects of these kits are similar to those of the standard kit …

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