Lixiao Zhen

A H-MnO2 nanoplatform for tumor microenvironment remodeling and multimodal synergistic therapy in prostate cancer

Haitao Zhang, D D Jiang, Luyao Huang, Lixiao Zhen et autres

The efficacy of chemotherapeutic drugs is inherently dose-dependent, and their clinical application is often limited by systemic toxicity and poor tumor selectivity. Manganese dioxide (MnO 2 ) nanomaterials have attracted considerable interest in nanomedicine due to their favorable biocompatibility, efficient cellular uptake, …

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Hollow nanosystem-boosting synergistic effects between photothermal therapy and chemodynamic therapy via self-supplied hydrogen peroxide and relieved hypoxia

Yunji Sun, Lixiao Zhen, Xu Lin, Peipei Li et autres

Nanomedicine-based photothermal therapy (PTT) has been considered as an excellent alternative for treatment of tumor tissue due to its high therapeutic efficiency and controllable range.

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Author response for "Hollow nanosystem-boosting synergistic effect between photothermal therapy and chemodynamic therapy via self-supplied hydrogen peroxide and relieved hypoxia"

Yunji Sun, Lixiao Zhen, Xu Lin, Peipei Li et autres

Author response for "Hollow nanosystem-boosting synergistic effect between photothermal therapy and chemodynamic therapy via self-supplied hydrogen peroxide and relieved hypoxia"

Yunji Sun, Lixiao Zhen, Xu Lin, Peipei Li et autres

CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway

Xiue Ma, Liming Gao, Rucun Ge, Tianyou Yuan et autres

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Imp7 siRNA nanoparticles protect against mechanical ventilation-associated liver injury by inhibiting HMGB1 production and NETs formation

Ning Ding, Hui Xiao, Lixiao Zhen, Huiqing Li et autres

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Systemic cytokines inhibition with Imp7 siRNA nanoparticle ameliorates gut injury in a mouse model of ventilator-induced lung injury

Ning Ding, Hui Xiao, Lixiao Zhen, Huiqing Li et autres

Mechanical ventilation (MV) may negatively affect the lungs and cause the release of inflammatory mediators, resulting in extra-pulmonary organ dysfunction. Studies have revealed systemically elevated levels of proinflammatory cytokines in animal models of ventilator-induced lung injury (VILI); however, whether these cytokines have …

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miR-301a-PTEN-AKT Signaling Induces Cardiomyocyte Proliferation and Promotes Cardiac Repair Post-MI

Lixiao Zhen, Qian Zhao, Jinhui Lü, Shengqiong Deng et autres

Adult hearts are hard to recover after cardiac injury due to the limited proliferative ability of cardiomyocytes. Emerging evidence indicates the induction of cell cycle reentry of cardiomyocytes by special treatment or stimulation, which offers adult heart regenerative potential. Herein, a microRNA …

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Starvation stress attenuates the miRNA-target interaction in suppressing breast cancer cell proliferation

Jinhui Lü, Chuyi Zhang, Junyi Han, Zhen Xu et autres

BACKGROUND: Emerging evidence has demonstrated the limited access to metabolic substrates as an effective approach to block cancer cell growth. The mechanisms remain unclear. Our previous work has revealed that miR-221/222 plays important role in regulating breast cancer development and progression through …

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MiR-301a promotes embryonic stem cell differentiation to cardiomyocytes

Lixiao Zhen, Yuying Gu, Qian Cheng Zhao, Huifang Zhu et autres

BACKGROUND: Cardiovascular disease is the leading cause of death worldwide. Tissue repair after pathological injury in the heart remains a major challenge due to the limited regenerative ability of cardiomyocytes in adults. Stem cell-derived cardiomyocytes provide a promising source for the cell …

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YY1 mediates TGF-β1-induced EMT and pro-fibrogenesis in alveolar epithelial cells

Chuyi Zhang, Xiaoping Zhu, Yifei Hua, Qian Zhao et autres

Pulmonary fibrosis is a chronic, progressive lung disease associated with lung damage and scarring. The pathological mechanism causing pulmonary fibrosis remains unknown. Emerging evidence suggests prominent roles of epithelial-mesenchymal transition (EMT) of alveolar epithelial cells (AECs) in myofibroblast formation and progressive pulmonary …

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Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells

Lingyu Meng, Cuicui Liu, Jinhui Lü, Qian Zhao et autres

MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed 'small RNA zipper'. It is designed to connect miRNA molecules end to end, forming a DNA-RNA duplex through a complementary interaction …

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