Takanari Miyamoto

Lysophosphatidic Acid (LPA) Salivary Species Detection and Whole-mount LPA Receptor Localization in Mouse Salivary Gland

D. Roselyn Cerutis, Devendra Kumar, Michael G. Nichols, Gabrielle Rae Roemer et autres

Abstract This study builds on our previous findings on the role of salivary lysophosphatidic acid (LPA) species in humans to investigate their presence, together with salivary gland LPA receptor (LPAR) expression in a Porphyromonas gingivalis -infected murine (C57BL/6J) model of periodontal disease …

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Development of an artificial intelligence platform to improve compliance in periodontal maintenance patients: A proof‐of‐concept study

Takanari Miyamoto, Michael McGuire, E. Todd Scheyer, Becki Cole et autres

BACKGROUND: The purpose of this study is to report on the development of an artificial intelligence (AI) model designed to improve compliance in periodontal maintenance patients. METHODS: Fifty adult patients (32 females and 18 males; aged 25 to 78 years) with diagnosis …

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A systematic review of a novel alloplast carbonate apatite granules

Martha E. Nunn, C. Rudick, Masahiko Nikaido, Takanari Miyamoto

The objectives of this study are to provide a systematic review of a novel alloplastic hard-tissue grafting material, carbonate apatite granules (CO3Ap-granules), to provide a clinical case presentation of CO3Ap-granules in periodontal surgery. The following three electronic databases were searched independently by …

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Entering, Linked with the Sphinx: Lysophosphatidic Acids Everywhere, All at Once, in the Oral System and Cancer

D. Roselyn Cerutis, Michael D. Weston, Takanari Miyamoto

Oral health is crucial to overall health, and periodontal disease (PDD) is a chronic inflammatory disease. Over the past decade, PDD has been recognized as a significant contributor to systemic inflammation. Here, we relate our seminal work defining the role of lysophosphatidic …

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Lysophosphatidic Acid (LPA) Salivary Species Detection and In Situ LPAR Localization in the Intact Mouse Salivary Gland

D. Roselyn Cerutis, Devendra Kumar, Michael G. Nichols, G. B. Roemer et autres

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Validity of fractal analysis of implants in individuals with healthy and diseased peri‐implant mucosa

Melissa Lang, Takanari Miyamoto, Martha E. Nunn

OBJECTIVE: The purpose of this study was to determine whether fractal analysis could discriminate the peri-implant trabecular bone between individuals with healthy peri-implant mucosa and peri-implant disease using digital periapical radiographs. MATERIAL AND METHODS: The electronic health records of patients with a …

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Application of 2017 New Classification of Periodontal Diseases and Conditions to Localized Aggressive Periodontitis: Case Series

Takanari Miyamoto, T. Kumagai, Shakeel Khan, Michael S. Reddy

INTRODUCTION: This case series illustrates the use of the new classification system of periodontal diseases and conditions. This case series highlights how the assessment of the rate of progression of periodontal disease, that is, grading, allows for the identification of individual patients, …

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The clinical efficacy of deproteinized bovine bone mineral with 10% collagen in conjunction with localized piezosurgical decortication enhanced orthodontics: A prospective observational study

Takanari Miyamoto, Melissa Lang, Shakeel Khan, Kota Kumagai et autres

BACKGROUND: Evidence exists on the clinical efficacy and safety of periodontally accelerated osteogenic orthodontics (PAOO) with "Piezocision"-a minimally invasive, flapless alternative to corticotomy for alveolar bone augmentation. Allograft has been extensively studied for alveolar bone augmentation in Piezocision; however, the use of …

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Surface Evaluation of the Combination of a Nylon and Traditional Partial Removable Dental Prosthesis: 3.5-year Follow-up Clinical Report

Masayasu Ito, Yasuhiro Tanimoto, Alvin G. Wee, Takanari Miyamoto et autres

A nylon partial removable dental prosthesis (PRDP) is aesthetically superior to a traditional PRDP. However, the nylon surface becomes rough after long-term use.

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Understanding the pathophysiology behind chairside diagnostics and genetic testing for IL‐1 and IL‐6

Courtney P. Rudick, Melissa Lang, Takanari Miyamoto

In order for chairside diagnostic testing to make an impact on dental therapy, practitioners require a better understanding of genetic mutations contributing to the pathophysiology of periodontal disease. Commensal and pathogenic bacterial colonization in oral cavity tissues produces a cascade of proinflammatory …

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Lysophosphatidic Acid Regulates the Vitamin D Receptor and its Metabolism‐Related Genes in Human Gingival Fibroblasts

D. Roselyn Cerutis, Michael D. Weston, Martha E. Nunn, David E. Williams et autres

Our laboratory has established that lysophosphatidic acid (LPA) regulates the biology of human oral fibroblasts, and that gingival fibroblasts (GF) express the LPA1–5 receptor subtypes. We have also shown that LPA 18:1 controls immediate‐early GF gene transcription of inflammatory cytokines, and of …

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Triggering receptor expressed on myeloid cells in the pathogenesis of periodontitis: potential novel treatment strategies

Courtney P. Rudick, Takanari Miyamoto, Melissa Lang, Devendra K. Agrawal

INTRODUCTION: Periodontal diseases are polymicrobial inflammatory disorders of the tissue, ligament, and bone structures supporting teeth. Periodontitis (inflammation with corresponding loss of attachment) affects 40-50% of adults. Recently, members of the Triggering Receptor on Myeloid Cell (TREM) family have been studied to …

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